Key features and details
- Human monoclonal to CD20
- Suitable for: Neutralising
- Reacts with: Human
- Isotype: IgG1
Product nameAnti-CD20 antibody
See all CD20 primary antibodies
DescriptionHuman monoclonal to CD20
Tested applicationsSuitable for: Neutralisingmore details
Species reactivityReacts with: Human
Fusion protein corresponding to Human CD20. Features the constant region of the Human IgG1 isotype and the variable region of CD20, expressed in a 293 freestyle cell expression system (HEK293).
Database link: P11836
Epitopeab206936 binds to Human CD20 extracellular region amino acids 142- 184, where it acts as an agonist of the CD20 protein.
- WIL2-S cells
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Constituents: PBS, 0.8% Sodium chloride, 0.02% Potassium chloride, 20% Glycerol
Endotoxin Level: <1 EU/ µg
Concentration information loading...
PurityProtein A purified
Light chain typekappa
Our Abpromise guarantee covers the use of ab206936 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Neutralising||Use at an assay dependent concentration.
EC50: 0.24 μg/ml
FunctionThis protein may be involved in the regulation of B-cell activation and proliferation.
Tissue specificityExpressed on B-cells.
Involvement in diseaseDefects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
Sequence similaritiesBelongs to the MS4A family.
modificationsPhosphorylated. Might be functionally regulated by protein kinase(s).
- Information by UniProt
- APY antibody
- ATOPY antibody
- B lymphocyte antigen CD20 antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab206936 has not yet been referenced specifically in any publications.