The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration. PubMed: 19139298
Use at an assay dependent concentration. Predicted molecular weight: 33 kDa.
Use at an assay dependent concentration.
1/300. Antigen retrieval is not essential but may optimise staining.
This protein may be involved in the regulation of B-cell activation and proliferation.
Expressed on B-cells.
Involvement in disease
Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
Belongs to the MS4A family.
Phosphorylated. Might be functionally regulated by protein kinase(s).
Webb GM et al. The human IL-15 superagonist ALT-803 directs SIV-specific CD8+T cells into B-cell follicles. Blood Adv2:76-84 (2018).
Read more (PubMed: 29365313) »
Miles B et al. Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection. PLoS Pathog12:e1005924 (2016).
IHC (PFA fixed)
Read more (PubMed: 27716848) »