The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ab97679 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
This protein may be involved in the regulation of B-cell activation and proliferation.
Expressed on B-cells.
Involvement in disease
Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
Belongs to the MS4A family.
Phosphorylated. Might be functionally regulated by protein kinase(s).
Sherman DJ et al. A differential cell capture assay for evaluating antibody interactions with cell surface targets. Anal Biochem401:173-81 (2010).
Read more (PubMed: 20178770) »
Chan HT et al. CD20-induced lymphoma cell death is independent of both caspases and its redistribution into triton X-100 insoluble membrane rafts. Cancer Res63:5480-9 (2003).
Read more (PubMed: 14500384) »