Overview

  • Product name

    Anti-CD21 antibody [1F8], prediluted
    See all CD21 primary antibodies
  • Description

    Mouse monoclonal [1F8] to CD21, prediluted
  • Host species

    Mouse
  • Specificity

    This antibody reacts with CD21 antigen of MW 145 kD, present on the surface of mature B cells. The antigen is present at high density on follicular dendritic cells. CD21 is involved in transmitting growth-promoting signals to the interior of the B cell.
  • Tested applications

    Suitable for: IHC-P, IHC-Frmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Purified receptor for the C3d fragment of the third complement component CR2, from human tonsil.

  • Positive control

    • Tonsil.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C.
  • Storage buffer

    Preservative: 0.1% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Monoclonal
  • Clone number

    1F8
  • Isotype

    IgG1
  • Light chain type

    kappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab7290 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
IHC-Fr
  • Application notes
    IHC-P: Use at an assay dependent dilution.
    IHC-Fr: Use at an assay dependent dilution.
    We suggest an incubation period of 30 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation should be determined by the user.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation.
    • Tissue specificity

      Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen.
    • Involvement in disease

      Genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) [MIM:610927]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
    • Sequence similarities

      Belongs to the receptors of complement activation (RCA) family.
      Contains 15 Sushi (CCP/SCR) domains.
    • Cellular localization

      Membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • C3DR antibody
      • CD 21 antibody
      • CD21 antibody
      • Complement C3d receptor 2 antibody
      • Complement C3d receptor antibody
      • Complement component (3d/Epstein Barr virus) receptor 2 antibody
      • Complement receptor type 2 antibody
      • CR antibody
      • Cr2 antibody
      • CR2_HUMAN antibody
      • CVID7 antibody
      • EBV receptor antibody
      • EBV-R antibody
      • Epstein Barr virus receptor antibody
      • Epstein-Barr virus receptor antibody
      • EVBR antibody
      • SLEB9 antibody
      see all

    References

    ab7290 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab7290.
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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