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    cd21cd35-antibody-7e9-ab155579.pdf

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Immunology Adaptive Immunity B Cells CD
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Anti-CD21+CD35 antibody [7E9] (ab155579)

  • Datasheet
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Key features and details

  • Rat monoclonal [7E9] to CD21+CD35
  • Reacts with: Mouse
  • Isotype: IgG2a

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Secondary
Product image
Goat Anti-Rat IgG H&L (HRP) (ab97057)

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Overview

  • Product name

    Anti-CD21+CD35 antibody [7E9]
    See all CD21+CD35 primary antibodies
  • Description

    Rat monoclonal [7E9] to CD21+CD35
  • Host species

    Rat
  • Specificity

    ab155579 does not inhibit rosette formation between 2PK3 cells and Crd-coated SRBC indicator cells.
  • Species reactivity

    Reacts with: Mouse
  • Immunogen

    Purified mouse CD35 from serum.

  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C.
  • Storage buffer

    Preservative: 0.02% Sodium azide
    Constituents: 99% PBS, 0.1% BSA
  • Concentration information loading...
  • Purity

    Protein G purified
  • Clonality

    Monoclonal
  • Clone number

    7E9
  • Isotype

    IgG2a
  • Research areas

    • Immunology
    • Adaptive Immunity
    • B Cells
    • CD
    • Immunology
    • Adaptive Immunity
    • T Cells
    • CD
    • Cardiovascular
    • Blood
    • Blood Cell Antigens
    • RBC Antigens
    • Blood Group Antigens
    • Immunology
    • Innate Immunity
    • Myeloid Cells
    • Microbiology
    • Protein
    • Human Protein
    • Receptor

Associated products

  • Compatible Secondaries

    • Goat Anti-Rat IgG H&L (Alexa Fluor® 488) (ab150157)
    • Goat Anti-Rat IgG H&L (HRP) (ab205720)
  • Isotype control

    • Rat IgG2a, kappa monoclonal [RTK2758] - Isotype Control (ab18450)

Applications

  • Application notes
    Is unsuitable for FuncS.
  • Target

    • Relevance

      CD21 also known as complement receptor 2 (CR2), C3d receptor or EBV receptor is a 140 kDa protein. CD21 is a glycosylated type I transmembrane protein consisting of an extracellular face of a series of 15 or 16 CCP domains. CD21 is the receptor for complement components C3d and iC3b as well as the Epstein-Barr virus (EBV) glycoprotein gp350/220. The soluble CD21 (sCD21) was shown to efficiently trigger CD23 signalling pathways in human monocytes. By inducing release of proinflammatory cytokines and upregulating expression of molecules involved in antigen presentation, sCD21 modulates critical monocyte functions that may be relevant to allergic and inflammatory disorders. The CD35 gene encodes a membrane glycoprotein found on peripheral blood cells, glomerular podocytes, and follicular dendritic cells. The protein is a receptor for complement components C3b and C4b and regulates the activity of the complement cascade. Variation in this protein is the basis of the Knops blood group system. The two most common alleles, F and S, differ by 8 exons and are thought to be the result of an unequal crossover event. A secreted form of the protein present in plasma has been described, but its full length nature has not been determined.
    • Cellular localization

      Membrane; Single pass type I membrane protein.
    • Database links

      • Entrez Gene: 12902 Mouse
      • SwissProt: P19070 Mouse
      • Alternative names

        • C3 binding protein antibody
        • C3b/C4b receptor antibody
        • C3BR antibody
        • C3DR antibody
        • C4BR antibody
        • CD 21 antibody
        • CD 35 antibody
        • CD21 antigen antibody
        • CD35 antigen antibody
        • Complement C3d receptor antibody
        • Complement component (3b/4b) receptor 1 antibody
        • Complement component (3d/Epstein Barr virus) receptor 2 antibody
        • Complement component receptor 1 antibody
        • Complement component receptor 2 antibody
        • Complement receptor 1 antibody
        • Complement receptor type 1 antibody
        • Complement receptor type 2 antibody
        • Cr 2 antibody
        • CR1 antibody
        • Cr2 antibody
        • EBV receptor antibody
        • Epstein Barr virus receptor antibody
        • KN antibody
        • Knops blood group antigen antibody
        • SLEB9 antibody
        see all

      Protocols

      • Flow cytometry protocols
      • Immunoprecipitation protocols
      • Immunocytochemistry & immunofluorescence protocols
      • Western blot protocols

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
    • References (0)

      Publishing research using ab155579? Please let us know so that we can cite the reference in this datasheet.

      ab155579 has not yet been referenced specifically in any publications.

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