Overview

  • Product name
    Anti-CD21+CD35 antibody [7E9]
  • Description
    Rat monoclonal [7E9] to CD21+CD35
  • Host species
    Rat
  • Specificity
    ab155579 does not inhibit rosette formation between 2PK3 cells and Crd-coated SRBC indicator cells.
  • Tested applications
    Suitable for: WB, IP, Flow Cyt, ICC/IFmore details
    Unsuitable for: FuncS
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Purified mouse CD35 from serum.

Properties

Applications

Our Abpromise guarantee covers the use of ab155579 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50. Predicted molecular weight: 113 kDa.
IP Use at an assay dependent concentration.
Flow Cyt 1/50.

ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

 

ICC/IF Use at an assay dependent concentration.
  • Application notes
    Is unsuitable for FuncS.
  • Target

    • Relevance
      CD21 also known as complement receptor 2 (CR2), C3d receptor or EBV receptor is a 140 kDa protein. CD21 is a glycosylated type I transmembrane protein consisting of an extracellular face of a series of 15 or 16 CCP domains. CD21 is the receptor for complement components C3d and iC3b as well as the Epstein-Barr virus (EBV) glycoprotein gp350/220. The soluble CD21 (sCD21) was shown to efficiently trigger CD23 signalling pathways in human monocytes. By inducing release of proinflammatory cytokines and upregulating expression of molecules involved in antigen presentation, sCD21 modulates critical monocyte functions that may be relevant to allergic and inflammatory disorders. The CD35 gene encodes a membrane glycoprotein found on peripheral blood cells, glomerular podocytes, and follicular dendritic cells. The protein is a receptor for complement components C3b and C4b and regulates the activity of the complement cascade. Variation in this protein is the basis of the Knops blood group system. The two most common alleles, F and S, differ by 8 exons and are thought to be the result of an unequal crossover event. A secreted form of the protein present in plasma has been described, but its full length nature has not been determined.
    • Cellular localization
      Membrane; Single pass type I membrane protein.
    • Database links
    • Alternative names
      • C3 binding protein antibody
      • C3b/C4b receptor antibody
      • C3BR antibody
      • C3DR antibody
      • C4BR antibody
      • CD 21 antibody
      • CD 35 antibody
      • CD21 antigen antibody
      • CD35 antigen antibody
      • Complement C3d receptor antibody
      • Complement component (3b/4b) receptor 1 antibody
      • Complement component (3d/Epstein Barr virus) receptor 2 antibody
      • Complement component receptor 1 antibody
      • Complement component receptor 2 antibody
      • Complement receptor 1 antibody
      • Complement receptor type 1 antibody
      • Complement receptor type 2 antibody
      • Cr 2 antibody
      • CR1 antibody
      • Cr2 antibody
      • EBV receptor antibody
      • Epstein Barr virus receptor antibody
      • KN antibody
      • Knops blood group antigen antibody
      • SLEB9 antibody
      see all

    References

    ab155579 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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