Key features and details
- Rat monoclonal [7E9] to CD21+CD35
- Reacts with: Mouse
- Isotype: IgG2a
Product nameAnti-CD21+CD35 antibody [7E9]
See all CD21+CD35 primary antibodies
DescriptionRat monoclonal [7E9] to CD21+CD35
Specificityab155579 does not inhibit rosette formation between 2PK3 cells and Crd-coated SRBC indicator cells.
Species reactivityReacts with: Mouse
Purified mouse CD35 from serum.
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Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferPreservative: 0.02% Sodium azide
Constituents: 99% PBS, 0.1% BSA
Concentration information loading...
PurityProtein G purified
RelevanceCD21 also known as complement receptor 2 (CR2), C3d receptor or EBV receptor is a 140 kDa protein. CD21 is a glycosylated type I transmembrane protein consisting of an extracellular face of a series of 15 or 16 CCP domains. CD21 is the receptor for complement components C3d and iC3b as well as the Epstein-Barr virus (EBV) glycoprotein gp350/220. The soluble CD21 (sCD21) was shown to efficiently trigger CD23 signalling pathways in human monocytes. By inducing release of proinflammatory cytokines and upregulating expression of molecules involved in antigen presentation, sCD21 modulates critical monocyte functions that may be relevant to allergic and inflammatory disorders. The CD35 gene encodes a membrane glycoprotein found on peripheral blood cells, glomerular podocytes, and follicular dendritic cells. The protein is a receptor for complement components C3b and C4b and regulates the activity of the complement cascade. Variation in this protein is the basis of the Knops blood group system. The two most common alleles, F and S, differ by 8 exons and are thought to be the result of an unequal crossover event. A secreted form of the protein present in plasma has been described, but its full length nature has not been determined.
Cellular localizationMembrane; Single pass type I membrane protein.
- C3 binding protein antibody
- C3b/C4b receptor antibody
- C3BR antibody
ab155579 has not yet been referenced specifically in any publications.