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Cardiovascular Blood Blood Cell Antigens
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RecombinantRabMAb

Recombinant Anti-CD239/BCAM antibody [EPR4164] (ab111181)

  • Datasheet
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)
  • Anti-CD239/BCAM antibody [EPR4164] (ab111181)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR4164] to CD239/BCAM
  • Suitable for: IHC-P
  • Reacts with: Human

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Overview

  • Product name

    Anti-CD239/BCAM antibody [EPR4164]
    See all CD239/BCAM primary antibodies
  • Description

    Rabbit monoclonal [EPR4164] to CD239/BCAM
  • Host species

    Rabbit
  • Tested Applications & Species

    Application Species
    IHC-P
    Human
    See all applications and species data
  • Immunogen

    Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

  • Positive control

    • Human Breast Carcinoma and Tonsil Tissues.
  • General notes

     

     

     This product was previously labelled as CD239

     

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • Storage buffer

    pH: 7.20
    Preservative: 0.05% Sodium azide
    Constituents: 0.1% BSA, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant
  • Concentration information loading...
  • Purity

    Tissue culture supernatant
  • Clonality

    Monoclonal
  • Clone number

    EPR4164
  • Isotype

    IgG
  • Research areas

    • Cardiovascular
    • Blood
    • Blood Cell Antigens
    • Cardiovascular
    • Blood
    • Other
    • Immunology
    • Immunoglobulins
    • Receptors
    • Cardiovascular
    • Atherosclerosis
    • Thrombosis
    • Other

Associated products

  • Alternative Versions

    • Anti-CD239/BCAM antibody [EPR4164] - BSA and Azide free (ab247939)
  • Isotype control

    • Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab111181 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
IHC-P
Human
Application Abreviews Notes
IHC-P
1/100 - 1/250. Perform heat mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol.
Notes
IHC-P
1/100 - 1/250. Perform heat mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol.
  • Application notes
    Is unsuitable for Flow Cyt,IP or WB.
  • Target

    • Function

      Laminin alpha-5 receptor. May mediate intracellular signaling.
    • Tissue specificity

      Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls.
    • Sequence similarities

      Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 2 Ig-like V-type (immunoglobulin-like) domains.
    • Developmental stage

      Is under developmental control in liver and may also be regulated during differentiation in other tissues. Up-regulated following malignant transformation in some cell types.
    • Post-translational
      modifications

      Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin.
    • Cellular localization

      Membrane.
    • Target information above from: UniProt accession P50895 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 4059 Human
      • Omim: 612773 Human
      • SwissProt: P50895 Human
      • Unigene: 625725 Human
      • Alternative names

        • Antigen identified by monoclonal antibody F8 antibody
        • AU antibody
        • Auberger B antigen antibody
        • B CAM cell surface glycoprotein antibody
        • B cell adhesion molecule antibody
        • B-CAM cell surface glycoprotein antibody
        • Basal cell adhesion molecule (Lu and Au blood groups) antibody
        • Basal cell adhesion molecule (Lutheran blood group) antibody
        • Basal cell adhesion molecule antibody
        • Basal cell adhesion molecule Lu and Au blood groups antibody
        • Basal cell adhesion molecule Lutheran blood group antibody
        • Bcam antibody
        • BCAM_HUMAN antibody
        • CD239 antibody
        • CD239 antigen antibody
        • F8/G253 antigen antibody
        • Glycoprotein 95kDa antibody
        • LU antibody
        • Lutheran antibody
        • Lutheran antigen antibody
        • Lutheran blood group (Auberger b antigen included) antibody
        • Lutheran blood group Auberger b antigen included antibody
        • Lutheran blood group glycoprotein antibody
        • MSK19 antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)

        ab111181 at 1/100 dilution staining CD239/BCAM in Paraffin-embedded Human breast carcinoma tissue by Immunohistochemistry.

        Perform heat mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol.

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)

        ab111181 at 1/100 dilution staining CD239/BCAM in Paraffin-embedded Human tonsil tissue by Immunohistochemistry.

        Perform heat mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol.

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)

        ab111181 showing positive staining in Thyroid gland carcinoma tissue.

        Perform heat mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol.

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)

        ab111181 showing positive staining in Normal stomach tissue.

        Perform heat mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol.

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)

        ab111181 showing positive staining in Normal ovary tissue.

        Perform heat mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol.

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)

        ab111181 showing positive staining in Normal liver tissue.

        Perform heat mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol.

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)

        ab111181 showing positive staining in Normal kidney tissue.

        Perform heat mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol.

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)

        ab111181 showing positive staining in Hepatocellular carcinoma tissue.

        Perform heat mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol.

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD239/BCAM antibody [EPR4164] (ab111181)

        ab111181 showing negative staining in Normal heart tissue.

        Perform heat mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol.

      • Anti-CD239/BCAM antibody [EPR4164] (ab111181)
        Anti-CD239/BCAM antibody [EPR4164] (ab111181)

      Protocols

      • Immunohistochemistry protocols

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
    • References (1)

      Publishing research using ab111181? Please let us know so that we can cite the reference in this datasheet.

      ab111181 has been referenced in 1 publication.

      • Tang R  et al. Differentiation of human induced pluripotent stem cells into nucleus pulposus-like cells. Stem Cell Res Ther 9:61 (2018). PubMed: 29523190

      Customer reviews and Q&As

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