Overview

  • Product name

  • Description

    Rabbit polyclonal to CD252
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human CD252 aa 102-131 conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary. NP_003317.1.
    Sequence:

    LISLKGYFS QEVNISLHYQ KDEEPLFQLK K


    Database link: P23510

  • Positive control

    • CEM cell line lysates; Human skeletal muscle and Human heart tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab211287 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/1000. Predicted molecular weight: 21 kDa.

Target

  • Function

    Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
  • Involvement in disease

    Genetic variations in TNFSF4 influence susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Note=The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T cell-APC interaction and the functional consequences of T cell activation, thereby destabilizing peripheral tolerance.
  • Sequence similarities

    Belongs to the tumor necrosis factor family.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CD 134L antibody
    • CD 252 antibody
    • CD134 antibody
    • CD134 ligand antibody
    • CD134L antibody
    • CD252 antibody
    • CD252 antigen antibody
    • glycoprotein 34 kd antibody
    • Glycoprotein Gp34 antibody
    • GP34 antibody
    • OX-40L antibody
    • OX40 antigen ligand antibody
    • OX40 ligand antibody
    • OX40L antibody
    • TAX transcriptionally-activated glycoprotein 1 antibody
    • TNFL4_HUMAN antibody
    • Tnfsf4 antibody
    • Tumor necrosis factor (ligand) superfamily member 4 antibody
    • Tumor necrosis factor ligand superfamily member 4 antibody
    • TXGP1 antibody
    see all

Images

  • Anti-CD252 antibody (ab211287) at 1/1000 dilution + CEM cell line lysates at 35 µg

    Predicted band size: 21 kDa

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human heart tissue labeling CD252 with ab211287 at 1/100 dilution.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human skeletal muscle labeling CD252 with ab211287 at 1/100 dilution.

References

ab211287 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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