• Product name
    Anti-CD26 antibody [11D7]
    See all CD26 primary antibodies
  • Description
    Mouse monoclonal [11D7] to CD26
  • Host species
  • Tested applications
    Suitable for: WB, IHC-P, Flow Cyt, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length Human CD26 produced in HEK293T cells (NP_001926)

  • Positive control
    • IHC-P: Liver tissue Flow Cyt: Hela cells WB: Transfected HEK293T cell lysate ICC/IF: Transfected COS7 cells



Our Abpromise guarantee covers the use of ab114033 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Predicted molecular weight: 88 kDa.
IHC-P 1/50.
Flow Cyt 1/100.

ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.


ICC/IF 1/100.


  • Function
    Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
  • Tissue specificity
    Expressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine, esophagus, ovary, breast and prostate glands. Not detected in lymphatic vessels in the lung, kidney, uterus, liver and stomach (at protein level). Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon.
  • Sequence similarities
    Belongs to the peptidase S9B family. DPPIV subfamily.
  • Domain
    The extracellular cysteine-rich region is necessary for association with collagen, dimer formation and optimal dipeptidyl peptidase activity.
  • Post-translational
    The soluble form (Dipeptidyl peptidase 4 soluble form also named SDPP) derives from the membrane form (Dipeptidyl peptidase 4 membrane form also named MDPP) by proteolytic processing.
    N- and O-Glycosylated.
    Phosphorylated. Mannose 6-phosphate residues in the carbohydrate moiety are necessary for interaction with IGF2R in activated T-cells. Mannose 6-phosphorylation is induced during T-cell activation.
  • Cellular localization
    Cell membrane. Apical cell membrane. Cell projection > invadopodium membrane. Cell projection > lamellipodium membrane. Cell junction. Membrane raft. Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids. Redistributed to membrane rafts in T-cell in a interleukin-12-dependent activation. Its interaction with CAV1 is necessary for its translocation to membrane rafts. Colocalized with PTPRC in membrane rafts. Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion. Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface and Secreted. Detected in the serum and the seminal fluid.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD26 antigen antibody
    • ADA-binding protein antibody
    • ADABP antibody
    • ADCP 2 antibody
    • ADCP-2 antibody
    • ADCP2 antibody
    • Adenosine deaminase complexing protein 2 antibody
    • CD 26 antibody
    • CD26 antibody
    • CD26 antigen 3 antibody
    • Dipeptidyl peptidase 4 antibody
    • Dipeptidyl peptidase 4 soluble form antibody
    • Dipeptidyl peptidase IV antibody
    • Dipeptidyl peptidase IV membrane form antibody
    • Dipeptidyl peptidase IV soluble form antibody
    • Dipeptidyl peptidase, intestinal antibody
    • Dipeptidylpeptidase 4 antibody
    • Dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2) antibody
    • Dipeptidylpeptidase IV antibody
    • DPP 4 antibody
    • DPP IV antibody
    • DPP IV estoenzyme antibody
    • DPP4 antibody
    • DPP4_HUMAN antibody
    • DPPIV antibody
    • Intestinal dipeptidyl peptidase antibody
    • T cell activation antigen CD26 antibody
    • T-cell activation antigen CD26 antibody
    • TP 103 antibody
    • TP103 antibody
    see all


  • All lanes : Anti-CD26 antibody [11D7] (ab114033) at 1/500 dilution

    Lane 1 : HEK293T cells were transfected with the pCMV6-ENTRY control cDNA for 48 hrs and lysed
    Lane 2 : HEK293T cells were transfected with the pCMV6-ENTRY DPP4 cDNA for 48 hrs and lysed

    Lysates/proteins at 5 µg per lane.

    Predicted band size: 88 kDa

    HEK293T cell lysates were generated from transient transfection of the cDNA clone (RC209466)
  • Immunohistochemical staining of paraffin embedded liver tissue using ab114033 at 1/50
  • Immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY DPP4, using ab114033 at 1/100
  • Flow cytometric analysis of Hela cells, using ab114033 at 1/100 (Red) compared to a nonspecific negative control antibody (Blue)


This product has been referenced in:
  • Song Y  et al. Expression of GLP-1 receptor and CD26 in human thyroid C-cells: The association of thyroid C-cell tumorigenesis with incretin-based medicine. Oncol Lett 13:2684-2690 (2017). IHC-P ; Human . Read more (PubMed: 28454451) »

See 1 Publication for this product

Customer reviews and Q&As

En principio ab28340 detecta una banda a un peso algo superior al esperado debido a modificaciones post translacionales, el otro, ab114033 muestra una banda a un peso molecular menor que también aparece en la calle que contiene el control a much...

Read More

Gracias por contactarnos.

Llevando a cabo una búsqueda de anticuerpos contra las proteínas indicadas puedo sugerirte las siguientes alternativas:

Contra CD26: https://www.abcam.com/cd26-antibody-ab28340.html o https://...

Read More

Thank you for confirming this information and for your help and cooperation with this case.

As requested, I have asked our accounting department to issue you with a credit note. This can then be redeemed against the invoice of a future order...

Read More

Thank you for taking the time to complete our questionnaire and contact us. I am sorry to hear you have had difficulty obtaining satisfactory results from this antibody.

The details you have kindly provided will enable us to investigate this...

Read More

Vielen Dank für Ihre Anfrage. Ich kann Ihnen nun bestätigen, dass ab84384 (Anti-DBC1 antibody) eine Konzentration von ca. 1mg/ml hat. Außerdem kann ich Ihnen bestätigen, dass das Lot, das im Moment von ab114033 (Anti-CD26 antibody [11D7]) vorrätig i...

Read More


Sign up