Anti-CD33 antibody [3D6] (ab11031)
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Overview
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Product nameAnti-CD33 antibody [3D6]
See all CD33 primary antibodies -
DescriptionMouse monoclonal [3D6] to CD33
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Host speciesMouse
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Tested applicationsSuitable for: ELISAmore details
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Species reactivityReacts with: Mouse, Human
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Immunogen
CD33-Fc recombinant protein.
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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Storage bufferConstituent: PBS
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Concentration information loading... -
PurityProtein A purified
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ClonalityMonoclonal
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Clone number3D6
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MyelomaSp2/0-Ag14
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IsotypeIgG1
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Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab11031 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| ELISA | Use at an assay dependent dilution. |
Target
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FunctionPutative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
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Tissue specificityMonocytic/myeloid lineage cells.
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Sequence similaritiesBelongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
DomainContains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
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Post-translational
modificationsPhosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6. -
Cellular localizationCell membrane.
- Information by UniProt
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Database links
- Entrez Gene: 945 Human
- Entrez Gene: 12489 Mouse
- Omim: 159590 Human
- SwissProt: P20138 Human
- SwissProt: Q63994 Mouse
- Unigene: 83731 Human
- Unigene: 140157 Mouse
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Alternative names
- CD 33 antibody
- CD33 antibody
- CD33 antigen (gp67) antibody
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Datasheets and documents
References
ab11031 has not yet been referenced specifically in any publications.
