Overview

  • Product name
    Anti-CD38 antibody [FS02]
    See all CD38 primary antibodies
  • Description
    Mouse monoclonal [FS02] to CD38
  • Host species
    Mouse
  • Specificity
    This antibody reacts with a type II membrane glycopeptide with a transmembrane sequence near the NH2-terminus.
  • Tested applications
    Suitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human

Properties

Applications

Our Abpromise guarantee covers the use of ab1260 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
  • Application notes
    HIV Syndromes and other clinical situations characterized by lymphocyte in vivoactivation in human lysed whole peripheral blood or mononuclear cells separated by density gradient.

    CD38 immunofluorescence analysis can be performed on a flow cytometerequipped with an excitation source of 488nm and fitted with logarithmic amplifiers.

    10µl ofCD38 is sufficient for labelling of 1x106 cells.
  • Target

    • Function
      Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
    • Tissue specificity
      Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
    • Sequence similarities
      Belongs to the ADP-ribosyl cyclase family.
    • Developmental stage
      Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.
    • Cellular localization
      Membrane.
    • Information by UniProt
    • Database links
    • Form
      There are 2 isoforms produced by alternative splicing.
    • Alternative names
      • Acute lymphoblastic leukemia cells antigen CD38 antibody
      • ADP ribosyl cyclase 1 antibody
      • ADP ribosyl cyclase antibody
      • ADP ribosyl cyclase/cyclic ADP-ribose hydrolase antibody
      • ADP-ribosyl cyclase 1 antibody
      • ADPRC 1 antibody
      • ADPRC1 antibody
      • cADPr hydrolase 1 antibody
      • CD 38 antibody
      • CD38 antibody
      • CD38 antigen (p45) antibody
      • CD38 antigen antibody
      • CD38 molecule antibody
      • Cd38-rs1 antibody
      • CD38_HUMAN antibody
      • CD38H antibody
      • Cyclic ADP ribose hydrolase antibody
      • Cyclic ADP ribose hydrolase 1 antibody
      • Cyclic ADP-ribose hydrolase 1 antibody
      • EC 3.2.2.5 antibody
      • Ecto nicotinamide adenine dinucleotide glycohydrolase antibody
      • I-19 antibody
      • I19 (mouse) antibody
      • Lymphocyte differentiation antigen CD38 antibody
      • NAD(+) nucleosidase antibody
      • NIM-R5 antigen antibody
      • NIMR5 antigen (mouse) antibody
      • OTTHUMP00000158633 antibody
      • OTTHUMP00000217743 antibody
      • p45 antibody
      • T10 antibody
      see all

    References

    ab1260 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    1-3 of 3 Abreviews or Q&A

    Answer


    I can confirm that ab1260 is not the agonistic monoclonal antibody (IB4) stated in the literature and unfortunately, we do not have this product in the catalogue. ab1260 has the clone number FS02 instead of IB4 and we have no information regarding whether it is an agonistic monoclonal antibody.

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    Answer

    Thank you for your enquiry.

    Having contacted the originators of these antibodies, we can let you know the following about the immunogens:

    ab2577: Tissue / cell preparation (Human thymocytes in foetus). According to our information the epitope mapping was not done. Only its location to the extracellular portion of the protein is known.

    ab93941: Purified recombinant fragment of Human CD38 expressed in E. coli.The peptide maps between amino acids 171 and 292.

    ab108403: A synthetic peptide corresponding to residues on the C terminus of Human CD38. The peptide maps between amino acids 275 and 300, on the C-terminus of human CD38 (UniProt: P28907).

    ab49644: Recombinant fusion protein corresponding to the extracellular region of human CD38 molecule. Unfortunately, futher details of this immunogen sequence are not available.

    ab1260: I am sorry but we do know the immunogen sequence or the range of amino acids or the region of the peptide from which it is derived. The producer of the hybridoma did not give us this kind of information.

    ab34283: The details of the immunogen for this antibody are also not available.

    ab75231: The antibody, CD 38 was raised to a prokaryotic recombinant protein corresponding to the extracellular region of the CD38 molecule. This region corresponds to amino acids 45-300. Unfortunately, the antibody has not been epitope mapped in order to determine the exact amino acid sequence to which it binds.

    ab91390: This monoclonal was development using as immunogen whole cell of human acute lymphoblastic B leukaemia. The antibody has also not been epitope mapped.

    ab9504: Nawalma cell line. The antibody has also not been epitope mapped.

    We aim to provide as much information as possible to customers, so I am sorry that this has not entirely been possible on this occasion. I hope this information is nevertheless helpful to you. Please do not hesitate to contact us if you need any more advice or information, or if we could be of any help in choosing the most suitable antibody for your experimental layout.

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    Answer

    Thank you for your email. Ab1260 has been used in the following two publications, please refer to them for more information regarding this antibody: Morra M et al. CD38 is functionally dependent on the TCR/CD3 complex in human T cells. FASEB J 12:581-92 (1998). PubMed: 9576485 Zupo S et al. CD38 signaling by agonistic monoclonal antibody prevents apoptosis of human germinal center B cells. Eur J Immunol 24:1218-22 (1994). PubMed: 8181532

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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