Recombinant Anti-CD4 antibody [EPR6855] (ab133616)

Rabbit recombinant monoclonal CD4 antibody [EPR6855]. Validated in WB, IHC, Flow Cyt, ICC/IF and tested in Human. Cited in 48 publication(s). Independently reviewed in 9 review(s).

Publishing research using ab133616? Please let us know so that we can cite the reference in this datasheet.

ab133616 has been referenced in 58 publications.

  • Zhao W  et al. A disinhibitory mechanism biases Drosophila innate light preference. Nat Commun 10:124 (2019). ICC/IF ; Drosophila melanogaster . PubMed: 30631066
  • Forlani G  et al. HTLV-1 HBZ Protein Resides Exclusively in the Cytoplasm of Infected Cells in Asymptomatic Carriers and HAM/TSP Patients. Front Microbiol 10:819 (2019). ICC/IF ; Human . PubMed: 31080441
  • Liu H  et al. Lymphocyte nadir predicts tumor response and survival in locally advanced rectal cancer after neoadjuvant chemoradiotherapy: Immunologic relevance. Radiother Oncol 131:52-59 (2019). PubMed: 30773187
  • Dunk C  et al. Failure of Decidualization and Maternal Immune Tolerance Underlies Uterovascular Resistance in Intra Uterine Growth Restriction. Front Endocrinol (Lausanne) 10:160 (2019). PubMed: 30949130
  • Jiang Q  et al. CD19+ tumor-infiltrating B-cells prime CD4+ T-cell immunity and predict platinum-based chemotherapy efficacy in muscle-invasive bladder cancer. Cancer Immunol Immunother 68:45-56 (2019). IHC ; Human . PubMed: 30259082
  • Cai L  et al. Role of Tumor-Associated Macrophages in the Clinical Course of Pancreatic Neuroendocrine Tumors (PanNETs). Clin Cancer Res 25:2644-2655 (2019). IHC ; Human . PubMed: 30670493
  • Rahman MA  et al. Associations of Simian Immunodeficiency Virus (SIV)-Specific Follicular CD8+ T Cells with Other Follicular T Cells Suggest Complex Contributions to SIV Viremia Control. J Immunol 200:2714-2726 (2018). PubMed: 29507105
  • Wang C  et al. Elimination of CD4lowHLA-G+ T cells overcomes castration-resistance in prostate cancer therapy. Cell Res 28:1103-1117 (2018). PubMed: 30297869
  • Ohtaki Y  et al. Prognostic significance of PD-L1 expression and tumor infiltrating lymphocytes in large cell neuroendocrine carcinoma of lung. Am J Transl Res 10:3243-3253 (2018). PubMed: 30416665
  • Guo X  et al. Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing. Nat Med 24:978-985 (2018). PubMed: 29942094
  • Ortega MA  et al. Implication of the PI3K/Akt/mTOR Pathway in the Process of Incompetent Valves in Patients with Chronic Venous Insufficiency and the Relationship with Aging. Oxid Med Cell Longev 2018:1495170 (2018). PubMed: 30057669
  • Helsen CW  et al. The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity. Nat Commun 9:3049 (2018). IHC-P ; Human . PubMed: 30076299
  • Smolders J  et al. Tissue-resident memory T cells populate the human brain. Nat Commun 9:4593 (2018). IHC-P ; Human . PubMed: 30389931
  • Chen Q  et al. Human V?9Vd2-T Cells Synergize CD4+ T Follicular Helper Cells to Produce Influenza Virus-Specific Antibody. Front Immunol 9:599 (2018). IHC-P ; Mouse . PubMed: 29670614
  • Shi G  et al. Epigenetic silencing of sonic hedgehog elicits antitumor immune response and suppresses tumor growth by inhibiting the hedgehog signaling pathway in metastatic spine tumors in Sprague-Dawley rats. J Cell Biochem 119:9591-9603 (2018). PubMed: 30191602
  • Stahl EC  et al. Evaluation of the host immune response to decellularized lung scaffolds derived from a-Gal knockout pigs in a non-human primate model. Biomaterials 187:93-104 (2018). PubMed: 30312852
  • Kamiya T  et al. A novel method to generate T-cell receptor-deficient chimeric antigen receptor T cells. Blood Adv 2:517-528 (2018). IHC ; Mouse . PubMed: 29507075
  • Yuan Z  et al. SIVcpz closely related to the ancestral HIV-1 is less or non-pathogenic to humans in a hu-BLT mouse model. Emerg Microbes Infect 7:59 (2018). IHC-P ; Mouse . PubMed: 29615603
  • Liu B  et al. PD-1/PD-L1 expression in a series of intracranial germinoma and its association with Foxp3+ and CD8+ infiltrating lymphocytes. PLoS One 13:e0194594 (2018). IHC-P ; Human . PubMed: 29617441
  • Bagheri N  et al. Up-regulated Th17 cell function is associated with increased peptic ulcer disease in Helicobacter pylori-infection. Infect Genet Evol 60:117-125 (2018). PubMed: 29481961
  • Ng SY  et al. Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models. Nat Commun 9:2024 (2018). IHC-P ; Human . PubMed: 29789628
  • Jiang H  et al. Abnormal acetylation of FOXP3 regulated by SIRT-1 induces Treg functional deficiency in patients with abdominal aortic aneurysms. Atherosclerosis 271:182-192 (2018). ICC/IF . PubMed: 29524861
  • Szentpetery A  et al. Abatacept reduces synovial regulatory T-cell expression in patients with psoriatic arthritis. Arthritis Res Ther 19:158 (2017). IHC ; Human . PubMed: 28679449
  • Baratella M  et al. Cytoplasmic Localization of HTLV-1 HBZ Protein: A Biomarker of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). PLoS Negl Trop Dis 11:e0005285 (2017). ICC/IF ; Human . PubMed: 28095504
  • Chew V  et al. Delineation of an immunosuppressive gradient in hepatocellular carcinoma using high-dimensional proteomic and transcriptomic analyses. Proc Natl Acad Sci U S A 114:E5900-E5909 (2017). Human . PubMed: 28674001
  • Xiao F  et al. Sex-dependent aortic valve pathology in patients with rheumatic heart disease. PLoS One 12:e0180230 (2017). IHC-P ; Human . PubMed: 28662157
  • Romani B  et al. Functional conservation and coherence of HIV-1 subtype A Vpu alleles. Sci Rep 7:87 (2017). PubMed: 28273896
  • Tsuchiya K  et al. Frequency of CD4+CD161+ T Cell and Interleukin-10 Expression in Inflammatory Bowel Diseases. Acta Histochem Cytochem 50:21-28 (2017). PubMed: 28386147
  • Romani B  et al. Functional conservation and coherence of HIV-1 subtype A Vpu alleles. Sci Rep 7:44894 (2017). PubMed: 28317943
  • Bolognesi MM  et al. Multiplex Staining by Sequential Immunostaining and Antibody Removal on Routine Tissue Sections. J Histochem Cytochem 65:431-444 (2017). PubMed: 28692376
  • Chen Q  et al. Growth-induced stress enhances epithelial-mesenchymal transition induced by IL-6 in clear cell renal cell carcinoma via the Akt/GSK-3ß/ß-catenin signaling pathway. Oncogenesis 6:e375 (2017). IHC-P ; Human . PubMed: 28846080
  • Li W  et al. Systemic HIV-1 infection produces a unique glial footprint in humanized mouse brains. Dis Model Mech 10:1489-1502 (2017). IHC-P ; Human . PubMed: 29084769
  • Rao N  et al. Significance of Tumor-Infiltrating Lymphocytes and the Expression of Topoisomerase IIa in the Prediction of the Clinical Outcome of Patients with Triple-Negative Breast Cancer after Taxane-Anthracycline-Based Neoadjuvant Chemotherapy. Chemotherapy 62:246-255 (2017). IHC ; Human . PubMed: 28472798
  • Noyan F  et al. Prevention of Allograft Rejection by Use of Regulatory T Cells With an MHC-Specific Chimeric Antigen Receptor. Am J Transplant 17:917-930 (2017). IHC-P ; Human . PubMed: 27997080
  • Sundarasetty B  et al. Human Effector Memory T Helper Cells Engage with Mouse Macrophages and Cause Graft-versus-Host-Like Pathology in Skin of Humanized Mice Used in a Nonclinical Immunization Study. Am J Pathol 187:1380-1398 (2017). PubMed: 28432872
  • Dyring-Andersen B  et al. IL-17A and IL-22 producing neutrophils in psoriatic skin. Br J Dermatol N/A:N/A (2017). IHC . PubMed: 28369663
  • Deleage C  et al. Defining HIV and SIV Reservoirs in Lymphoid Tissues. Pathog Immun 1:68-106 (2016). PubMed: 27430032
  • Song Y  et al. Increased frequency of thymic T follicular helper cells in myasthenia gravis patients with thymoma. J Thorac Dis 8:314-22 (2016). IF, IHC ; Human . PubMed: 27076925
  • Haskett S  et al. Identification of Novel CD4+ T Cell Subsets in the Target Tissue of Sjögren's Syndrome and Their Differential Regulation by the Lymphotoxin/LIGHT Signaling Axis. J Immunol 197:3806-3819 (2016). PubMed: 27815440
  • Xiao LI  et al. Multiple myeloma-associated skin light chain amyloidosis: A case of misdiagnosis. Oncol Lett 11:3617-3620 (2016). IHC ; Human . PubMed: 27284363
  • Lopker MJ  et al. Derivation and Characterization of Pathogenic Transmitted/Founder Molecular Clones from Simian Immunodeficiency Virus SIVsmE660 and SIVmac251 following Mucosal Infection. J Virol 90:8435-53 (2016). PubMed: 27412591
  • Yuan Z  et al. Recapitulating Cross-Species Transmission of Simian Immunodeficiency Virus SIVcpz to Humans by Using Humanized BLT Mice. J Virol 90:7728-39 (2016). PubMed: 27307566
  • Li H  et al. Long-term health effects of persistent exposure to low-dose lr192 gamma-rays. Exp Ther Med 12:2695-2701 (2016). Fluorescent Cell Imaging ; Human . PubMed: 27698774
  • He J  et al. The influence of exendin-4 intervention on -obese diabetic mouse blood and the pancreatic tissue immune microenvironment. Exp Ther Med 12:2893-2898 (2016). Flow Cyt ; Mouse . PubMed: 27882092
  • Schuhmann MK  et al. Immunohistochemical Analysis of Cerebral Thrombi Retrieved by Mechanical Thrombectomy from Patients with Acute Ischemic Stroke. Int J Mol Sci 17:N/A (2016). IHC-P ; Human . PubMed: 26927082
  • Wang ZQ  et al. CD103 and Intratumoral Immune Response in Breast Cancer. Clin Cancer Res 22:6290-6297 (2016). IHC ; Human . PubMed: 27267849
  • Liu XD  et al. Resistance to Antiangiogenic Therapy Is Associated with an Immunosuppressive Tumor Microenvironment in Metastatic Renal Cell Carcinoma. Cancer Immunol Res 3:1017-29 (2015). PubMed: 26014097
  • Webb GJ  et al. The immunogenetics of primary biliary cirrhosis: A comprehensive review. J Autoimmun 64:42-52 (2015). IHC . PubMed: 26250073
  • Okita Y  et al. Alteration of CD4 T cell subsets in metastatic lymph nodes of human gastric cancer. Oncol Rep 34:639-47 (2015). IHC . PubMed: 26081040
  • Ni YH  et al. Distinct expression patterns of Toll-like receptor 7 in tumour cells and fibroblast-like cells in oral squamous cell carcinoma. Histopathology 67:730-9 (2015). IHC . PubMed: 25828894
  • Torrisi JS  et al. Lymphaticovenous bypass decreases pathologic skin changes in upper extremity breast cancer-related lymphedema. Lymphat Res Biol 13:46-53 (2015). IHC ; Human . PubMed: 25521197
  • Kurose K  et al. Increase in activated Treg in TIL in lung cancer and in vitro depletion of Treg by ADCC using an antihuman CCR4 mAb (KM2760). J Thorac Oncol 10:74-83 (2015). IHC-P ; Human . PubMed: 25325779
  • Hao XP  et al. Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection. Nat Commun 6:8020 (2015). IHC-P ; Rhesus monkey . PubMed: 26282376
  • Galvão AM  et al. Immune-endocrine cross-talk in reproductive biology and pathology. Mediators Inflamm 2014:856465 (2014). IHC . PubMed: 24872600
  • Fan Y  et al. Low intraprostatic DHT promotes the infiltration of CD8+ T cells in BPH tissues via modulation of CCL5 secretion. Mediators Inflamm 2014:397815 (2014). IHC-P ; Human . PubMed: 24808637
  • d'Ettorre G  et al. Reconstitution of intestinal CD4 and Th17 T cells in antiretroviral therapy suppressed HIV-infected subjects: implication for residual immune activation from the results of a clinical trial. PLoS One 9:e109791 (2014). IHC ; Human . PubMed: 25340778
  • Sereti I  et al. Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration. PLoS Pathog 10:e1003890 (2014). IHC ; Human . PubMed: 24497828
  • Schuetz A  et al. Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation. PLoS Pathog 10:e1004543 (2014). IHC ; Human . PubMed: 25503054

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