Anti-CD40 antibody [1C10] (ab25298)
Key features and details
- Rat monoclonal [1C10] to CD40
- Suitable for: Flow Cyt, IP, Functional Studies
- Reacts with: Mouse
- Isotype: IgG2a
Overview
-
Product name
Anti-CD40 antibody [1C10]
See all CD40 primary antibodies -
Description
Rat monoclonal [1C10] to CD40 -
Host species
Rat -
Specificity
ab25298 recognises CD40. -
Tested applications
Suitable for: Flow Cyt, IP, Functional Studiesmore details -
Species reactivity
Reacts with: Mouse -
Immunogen
The details of the immunogen for this antibody are not available.
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 8.20
Constituent: 100% Borate buffered saline -
Concentration information loading... -
Purity
Affinity purified -
Clonality
Monoclonal -
Clone number
1C10 -
Isotype
IgG2a -
Light chain type
kappa -
Research areas
Associated products
-
Alternative Versions
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab25298 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| Flow Cyt | ||
| IP | ||
| Functional Studies |
Application notes
Flow Cyt: Use at an assay dependent dilution.
FuncS (in vitro induction of proliferation of mature B lymphocytes): Use at an assay dependent dilution.
IP: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FuncS (in vitro induction of proliferation of mature B lymphocytes): Use at an assay dependent dilution.
IP: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
-
Function
Receptor for TNFSF5/CD40LG. -
Tissue specificity
B-cells and in primary carcinomas. -
Involvement in disease
Defects in CD40 are the cause of hyper-IgM immunodeficiency syndrome type 3 (HIGM3) [MIM:606843]; also known as hyper-IgM syndrome 3. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation. -
Sequence similarities
Contains 4 TNFR-Cys repeats. -
Cellular localization
Secreted and Cell membrane. - Information by UniProt
-
Database links
- Entrez Gene: 21939 Mouse
- SwissProt: P27512 Mouse
- Unigene: 271833 Mouse
-
Alternative names
- AI326936 antibody
- B cell associated molecule CD40 antibody
- B cell surface antigen CD40 antibody
see all
References
ab25298 has been referenced in 1 publication.
- Heath AW et al. Monoclonal antibodies to murine CD40 define two distinct functional epitopes. Eur J Immunol 24:1828-34 (1994). PubMed: 7519997
