Anti-CD40 antibody [1C10] (ab25298)
- Datasheet
- References (1)
- Protocols
Overview
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Product nameAnti-CD40 antibody [1C10]
See all CD40 primary antibodies -
DescriptionRat monoclonal [1C10] to CD40
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Host speciesRat
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Specificityab25298 recognises CD40.
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Tested applicationsSuitable for: Flow Cyt, IP, Functional Studiesmore details
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Species reactivityReacts with: Mouse
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Immunogen
The details of the immunogen for this antibody are not available.
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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Storage bufferpH: 8.20
Constituent: 100% Borate buffered saline -
Concentration information loading... -
PurityAffinity purified
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ClonalityMonoclonal
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Clone number1C10
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IsotypeIgG2a
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Light chain typekappa
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Research areas
Associated products
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Alternative Versions
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Compatible Secondaries
Applications
Our Abpromise guarantee covers the use of ab25298 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| Flow Cyt | ||
| IP | ||
| Functional Studies |
Application notes
Flow Cyt: Use at an assay dependent dilution.
FuncS (in vitro induction of proliferation of mature B lymphocytes): Use at an assay dependent dilution.
IP: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FuncS (in vitro induction of proliferation of mature B lymphocytes): Use at an assay dependent dilution.
IP: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
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FunctionReceptor for TNFSF5/CD40LG.
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Tissue specificityB-cells and in primary carcinomas.
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Involvement in diseaseDefects in CD40 are the cause of hyper-IgM immunodeficiency syndrome type 3 (HIGM3) [MIM:606843]; also known as hyper-IgM syndrome 3. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation.
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Sequence similaritiesContains 4 TNFR-Cys repeats.
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Cellular localizationSecreted and Cell membrane.
- Information by UniProt
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Database links
- Entrez Gene: 21939 Mouse
- SwissProt: P27512 Mouse
- Unigene: 271833 Mouse
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Alternative names
- AI326936 antibody
- B cell associated molecule CD40 antibody
- B cell surface antigen CD40 antibody
see all
References
This product has been referenced in:
- Heath AW et al. Monoclonal antibodies to murine CD40 define two distinct functional epitopes. Eur J Immunol 24:1828-34 (1994). Read more (PubMed: 7519997) »
