PE Anti-CD42a/GP-IX antibody [GR-P] (ab30399)
Key features and details
- PE Mouse monoclonal [GR-P] to CD42a/GP-IX
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG1
Overview
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Product name
PE Anti-CD42a/GP-IX antibody [GR-P]
See all CD42a/GP-IX primary antibodies -
Description
PE Mouse monoclonal [GR-P] to CD42a/GP-IX -
Host species
Mouse -
Conjugation
PE. Ex: 488nm, Em: 575nm -
Tested applications
Suitable for: Flow Cytmore details -
Species reactivity
Reacts with: Human -
Immunogen
Tissue, cells or virus corresponding to Human CD42a/GP-IX. Human red blood cells and platelets.
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Positive control
- Human peripheral blood platelets
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
pH: 7.40
Preservative: 0.09% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading...
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Purification notes
ab30399 was purified by ion exchange chromatography. -
Clonality
Monoclonal -
Clone number
GR-P -
Myeloma
NS1 -
Isotype
IgG1 -
Research areas
Associated products
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Alternative Versions
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab30399 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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Flow Cyt |
Notes |
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Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
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Function
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib. -
Involvement in disease
Defects in GP9 are a cause of Bernard-Soulier syndrome (BSS) [MIM:231200]; also known as giant platelet disease (GPD). BSS patients have unusually large platelets and have a clinical bleeding tendency. -
Sequence similarities
Contains 1 LRR (leucine-rich) repeat.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 2815 Human
- Omim: 173515 Human
- SwissProt: P14770 Human
- Unigene: 1144 Human
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Alternative names
- CD42a antibody
- Glycoprotein 9 antibody
- Glycoprotein IX antibody
see all
Datasheets and documents
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Datasheet download
References (1)
ab30399 has been referenced in 1 publication.
- Tehrani S et al. High-dose aspirin is required to influence plasma fibrin network structure in patients with type 1 diabetes. Diabetes Care 35:404-8 (2012). Flow Cyt ; Human . PubMed: 22148098