Recombinant Anti-CD42a/GP-IX antibody [EPR5295] (ab108304)
![Western blot - Anti-CD42a/GP-IX antibody [EPR5295] (ab108304)](https://www.abcam.com/ps/products/108/ab108304/Images/CD42a-Primary-antibodies-ab108304-1.jpg "Western blot - Anti-CD42a/GP-IX antibody [EPR5295] (ab108304)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR5295] to CD42a/GP-IX
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
Overview
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Product name
Anti-CD42a/GP-IX antibody [EPR5295]
See all CD42a/GP-IX primary antibodies -
Description
Rabbit monoclonal [EPR5295] to CD42a/GP-IX -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details
Unsuitable for: ICC,IHC-P or IP -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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Positive control
- Human platelet lysate
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General notes
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
Storage buffer
pH: 7.20
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant -
Concentration information loading... -
Purity
Tissue culture supernatant -
Clonality
Monoclonal -
Clone number
EPR5295 -
Isotype
IgG -
Research areas
Associated products
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Alternative Versions
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab108304 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB |
1/1000 - 1/10000. Predicted molecular weight: 19 kDa.
|
| Notes |
|---|
|
WB
1/1000 - 1/10000. Predicted molecular weight: 19 kDa. |
Target
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Function
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib. -
Involvement in disease
Defects in GP9 are a cause of Bernard-Soulier syndrome (BSS) [MIM:231200]; also known as giant platelet disease (GPD). BSS patients have unusually large platelets and have a clinical bleeding tendency. -
Sequence similarities
Contains 1 LRR (leucine-rich) repeat.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 2815 Human
- Omim: 173515 Human
- SwissProt: P14770 Human
- Unigene: 1144 Human
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Alternative names
- CD42a antibody
- Glycoprotein 9 antibody
- Glycoprotein IX antibody
see all
Images
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Western blot - Anti-CD42a/GP-IX antibody [EPR5295] (ab108304)Anti-CD42a/GP-IX antibody [EPR5295] (ab108304) at 1/1000 dilution + Human platelet lysate at 10 µg
Performed under reducing conditions.
Predicted band size: 19 kDa -
![Anti-CD42a/GP-IX antibody [EPR5295] (ab108304)](https://www.abcam.com/ps/products/108/ab108304/Images/ab108304-2-benefits-of-recombinant-antibodies.png)
Anti-CD42a/GP-IX antibody [EPR5295] (ab108304)
Datasheets and documents
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Datasheet download
References (0)
ab108304 has not yet been referenced specifically in any publications.
