Overview

  • Product name

    Anti-CD44v4 antibody [CD44v4/1219]
    See all CD44v4 primary antibodies
  • Description

    Mouse monoclonal [CD44v4/1219] to CD44v4
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human CD44v4. The exact sequence is proprietary. Recombinant fragment corresponding to the v4 domain of Human CD44 (exact sequence is proprietary).
    Database link: P16070

  • Positive control

    • Human Cervix and Tongue Squamous Cell Carcinoma tissues.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.05% Sodium azide
    Constituents: 99% PBS, 0.05% BSA
  • Concentration information loading...
  • Purity

    Protein A/G purified
  • Purification notes

    ab217901 is purified from Bioreactor Concentrate by Protein A/G.
  • Clonality

    Monoclonal
  • Clone number

    CD44v4/1219
  • Isotype

    IgG2a
  • Light chain type

    kappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab217901 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Relevance

    CD44 is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44 participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for CD44 gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. CD44 variant 4 may influence the progression of colorectal cancer.
  • Cellular localization

    Cell Membrane
  • Database links

  • Alternative names

    • CD44 antigen antibody
    • CD44 molecule (Indian blood group) antibody
    • CD44 molecule antibody
    • CDW44 antibody
    • Cell surface glycoprotein CD44 antibody
    • Chondroitin sulfate proteoglycan 8 antibody
    • CSPG8 antibody
    • ECMR III antibody
    • Epican antibody
    • Extracellular matrix receptor III antibody
    • GP90 lymphocyte homing/adhesion receptor antibody
    • HCELL antibody
    • Hematopoietic cell E and L selectin ligand antibody
    • Heparan sulfate proteoglycan antibody
    • Hermes antigen antibody
    • Homing function and Indian blood group system antibody
    • HUTCH I antibody
    • Hyaluronate receptor antibody
    • IN antibody
    • LHR antibody
    • MC56 antibody
    • MDU2 antibody
    • MDU3 antibody
    • MIC4 antibody
    • PGP1 antibody
    • Phagocytic glycoprotein I antibody
    • Soluble CD44 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human cervical squamous cell carcinoma tissue labeling CD44v4 with ab217901 at 1 µg/ml.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human tongue squamous cell carcinoma tissue labeling CD44v4 with ab217901 at 1 µg/ml.

References

ab217901 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab217901.
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