Overview

  • Product name

    Anti-CD44v6 antibody [CD44v6/1246]
    See all CD44v6 primary antibodies
  • Description

    Mouse monoclonal [CD44v6/1246] to CD44v6
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human CD44v6. The exact sequence is proprietary. Recombinant fragment corresponding to the v6 domain of Human CD44.
    Database link: P16070

  • Positive control

    • IHC-P: Human cervix carcinoma or tongue squamous cell carcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab217902 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
  • Tissue specificity

    Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.
  • Sequence similarities

    Contains 1 Link domain.
  • Domain

    The lectin-like LINK domain is responsible for hyaluronan binding.
  • Post-translational
    modifications

    Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.
    N- and O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638.
    Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.
  • Cellular localization

    Membrane. Colocalizes with actin in membrane protrusions at wounding edges.
  • Information by UniProt
  • Database links

  • Alternative names

    • CD44 antibody
    • CD44 antigen antibody
    • CD44 isoform(s) antibody
    • CD44 molecule (Indian blood group) antibody
    • CD44 molecule antibody
    • Cd44 variant(s) antibody
    • CD44_HUMAN antibody
    • Cd44v antibody
    • CDw44 antibody
    • Cell surface glycoprotein CD44 antibody
    • Chondroitin sulfate proteoglycan 8 antibody
    • CSPG8 antibody
    • ECMR-III antibody
    • Epican antibody
    • Extracellular matrix receptor III antibody
    • GP90 lymphocyte homing/adhesion receptor antibody
    • HCELL antibody
    • Hematopoietic cell E and L selectin ligand antibody
    • Heparan sulfate proteoglycan antibody
    • Hermes antigen antibody
    • Homing function and Indian blood group system antibody
    • HUTCH I antibody
    • HUTCH-I antibody
    • Hyaluronate receptor antibody
    • IN antibody
    • LHR antibody
    • MC56 antibody
    • MDU2 antibody
    • MDU3 antibody
    • MIC4 antibody
    • MUTCH I antibody
    • PGP 1 antibody
    • PGP-1 antibody
    • PGP-I antibody
    • Pgp1 antibody
    • Phagocytic glycoprotein 1 antibody
    • Phagocytic glycoprotein I antibody
    • Soluble CD44 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded human cervival carcinoma labeling CD44v6 with ab217902 at 0.5 µg/mL for 30 minutes at RT.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded human tongue carcinoma labeling CD44v6 with ab217902 at 0.5 µg/mL for 30 minutes at RT.

References

ab217902 has not yet been referenced specifically in any publications.

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