Product nameAnti-CD45RC antibody [MIL15]
See all CD45RC primary antibodies
DescriptionMouse monoclonal [MIL15] to CD45RC
Tested applicationsSuitable for: IHC-Fr, IHC-P, Flow Cytmore details
Species reactivityReacts with: Pig
Full length native protein (purified) (Pig). (Cells isolated from porcine mesenteric lymph node).
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.4
Preservative: 0.09% Sodium azide
Constituents: Tissue culture supernatant, 1.72% Tris HCl, 10% Fetal calf serum
PurityTissue culture supernatant
Our Abpromise guarantee covers the use of ab14125 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: Use at an assay dependent dilution.
IHC-Fr: Use at an assay dependent dilution.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
RelevanceThe CD45 family of cell surface glycoprotein antigens exist as a set of isoforms. The patterns of monoclonal antibody recognition of the CD45 phenotypes can be restricted (CD45RA, RB and RC), or broader, such as the CD45 T 200 species. The "restricted" subsets of this group arise as a result of translation of alternatively spliced mRNAs from exons A, B and C (exons 4, 5 and 6), where exons 3-15 encode the extracellular domain of the CD45 molecule. The restricted epitopes are differentially expressed on T and B lymphocytes, including functionally distinct T cells. CD45 (LCA) is a transmembrane phosphotyrosine phosphatase expressed on leucocytes. Myeloid cells do not express the RC isoform.
Cellular localizationMembrane; Single-pass type I membrane protein. Membrane raft. Note: Colocalized with DPP4 in membrane rafts.
- B220 antibody
- CD45 antibody
- CD45R antibody
ab14125 has not yet been referenced specifically in any publications.