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    cd46-antibody-mm1-ab180652.pdf

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Immunology Cell Type Markers CD Non-lineage
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Anti-CD46 antibody [MM1] (ab180652)

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Immunohistochemistry (Frozen sections) - Anti-CD46 antibody [MM1] (ab180652)

    Key features and details

    • Mouse monoclonal [MM1] to CD46
    • Suitable for: IHC-Fr
    • Reacts with: Rat
    • Isotype: IgG1

    You may also be interested in

    Protein
    Recombinant Human CD46 protein (ab151345)
    Secondary
    Product image
    Goat Anti-Mouse IgG H&L (HRP) (ab205719)

    View more associated products

    Overview

    • Product name

      Anti-CD46 antibody [MM1]
      See all CD46 primary antibodies
    • Description

      Mouse monoclonal [MM1] to CD46
    • Host species

      Mouse
    • Tested applications

      Suitable for: IHC-Frmore details
    • Species reactivity

      Reacts with: Rat
    • Immunogen

      Fusion protein corresponding to Rat CD46. Second and third SCR domains of CD46 fused to IgG-Fc.
      Database link: Q9Z0M4

    • Positive control

      • rat testis lysate.
    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
    • Storage buffer

      Preservative: 0.02% Sodium azide
      Constituents: 99% PBS, 0.1% BSA
    • Concentration information loading...
    • Purity

      Protein G purified
    • Clonality

      Monoclonal
    • Clone number

      MM1
    • Isotype

      IgG1
    • Research areas

      • Immunology
      • Cell Type Markers
      • CD
      • Non-lineage
      • Immunology
      • Innate Immunity
      • Complement
      • Regulatory

    Associated products

    • Compatible Secondaries

      • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
      • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
    • Isotype control

      • Mouse IgG1, kappa monoclonal [15-6E10A7] - Isotype Control (ab170190)
    • Recombinant Protein

      • Recombinant Human CD46 protein (ab151345)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab180652 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-Fr
    Use at an assay dependent concentration.
    Notes
    IHC-Fr
    Use at an assay dependent concentration.

    Target

    • Function

      Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
    • Tissue specificity

      Expressed by all cells except erythrocytes.
    • Involvement in disease

      Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2) [MIM:612922]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Patients with CD46 mutations seem to have an overall better prognosis compared to patients carrying CFH mutations.
    • Sequence similarities

      Contains 4 Sushi (CCP/SCR) domains.
    • Domain

      Sushi domains 1 and 2 are required for interaction with human adenovirus B PIV/FIBER protein and with Measles virus H protein. Sushi domains 2 and 3 are required for Herpesvirus 6 binding. Sushi domain 3 is required for Neisseria binding. Sushi domains 3 and 4 are required for interaction with Streptococcus pyogenes M protein and are the most important for interaction with C3b and C4b.
    • Post-translational
      modifications

      N-glycosylated on Asn-83; Asn-114 and Asn-273 in most tissues, but probably less N-glycosylated in testis. N-glycosylation on Asn-114 and Asn-273 is required for cytoprotective function. N-glycosylation on Asn-114 is required for Measles virus binding. N-glycosylation on Asn-273 is required for Neisseria binding. N-glycosylation is not required for human adenovirus binding.
      Extensively O-glycosylated in the Ser/Thr-rich domain. O-glycosylation is required for Neisseria binding but not for Measles virus or human adenovirus binding.
      In epithelial cells, isoforms B/D/F/H/J/L/3 are phosphorylated by YES1 in response to infection by Neisseria gonorrhoeae; which promotes infectivity. In T-cells, these isoforms may be phosphorylated by Lck.
    • Cellular localization

      Cytoplasmic vesicle > secretory vesicle > acrosome inner membrane. Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide.
    • Target information above from: UniProt accession P15529 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 29333 Rat
      • SwissProt: Q9Z0M4 Rat
      • Unigene: 163242 Rat
      • Alternative names

        • AHUS2 antibody
        • Antigen defined by monoclonal antibody TRA 2 10 antibody
        • Antigen identified by monoclonal antibody TRA 2 10 antibody
        • CD46 antibody
        • CD46 antigen antibody
        • CD46 antigen complement regulatory protein antibody
        • CD46 molecule antibody
        • CD46 molecule complement regulatory protein antibody
        • Complement membrane cofactor protein antibody
        • MCP antibody
        • MCP_HUMAN antibody
        • Measles virus receptor antibody
        • membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen) antibody
        • Membrane cofactor protein antibody
        • MGC26544 antibody
        • MIC10 antibody
        • TLX antibody
        • TRA2.10 antibody
        • Trophoblast leucocyte common antigen antibody
        • Trophoblast leukocyte common antigen antibody
        • Trophoblast lymphocyte cross reactive antigen antibody
        see all

      Images

      • Immunohistochemistry (Frozen sections) - Anti-CD46 antibody [MM1] (ab180652)
        Immunohistochemistry (Frozen sections) - Anti-CD46 antibody [MM1] (ab180652)

        Immunohistochemical staining of frozen sections of Rat kidney sections stained for CD46.

      Protocols

      • Immunohistochemistry protocols

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (0)

      Publishing research using ab180652? Please let us know so that we can cite the reference in this datasheet.

      ab180652 has not yet been referenced specifically in any publications.

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