Anti-CD62P antibody (ab59738)
Key features and details
- Rabbit polyclonal to CD62P
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-CD62P antibody
See all CD62P primary antibodies -
Description
Rabbit polyclonal to CD62P -
Host species
Rabbit -
Specificity
The antibody recognizes 84kDa CD62P. -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide surrounding amino acid 756 of mouse CD62P.
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Positive control
- Jurkat whole cell lysate (ab7899)
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General notes
This product is manufactured by BioVision, an Abcam company and was previously called 3633R P-Selectin Antibody.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.5% BSA -
Concentration information loading...
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Purification notes
affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab59738 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (1) |
Use a concentration of 0.5 - 4 µg/ml. Detects a band of approximately 84 kDa (predicted molecular weight: 91 kDa).
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Notes |
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WB
Use a concentration of 0.5 - 4 µg/ml. Detects a band of approximately 84 kDa (predicted molecular weight: 91 kDa). |
Target
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Function
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. -
Tissue specificity
Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface. -
Involvement in disease
Defects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. -
Sequence similarities
Belongs to the selectin/LECAM family.
Contains 1 C-type lectin domain.
Contains 1 EGF-like domain.
Contains 9 Sushi (CCP/SCR) domains. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 6403 Human
- Omim: 173610 Human
- SwissProt: P16109 Human
- Unigene: 73800 Human
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Alternative names
- Antigen CD62 antibody
- CD62 antibody
- CD62 antigen-like family member P antibody
see all
Images
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Anti-CD62P antibody (ab59738) at 0.5 µg/ml + Jurkat cell lysate
Predicted band size: 91 kDa
Observed band size: 84 kDa why is the actual band size different from the predicted?
Datasheets and documents
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SDS download
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Datasheet download
References (7)
ab59738 has been referenced in 7 publications.
- Strohbach A et al. Platelet apelin receptor expression is reduced in patients with acute myocardial infarction. Vascul Pharmacol 136:106808 (2021). PubMed: 33130016
- Song H et al. Thrombopoietic effects of CCAAT/enhancer-binding protein ß on the early-stage differentiation of megakaryocytes. Arch Biochem Biophys 703:108846 (2021). PubMed: 33744198
- Vitverova B et al. Long term effects of soluble endoglin and mild hypercholesterolemia in mice hearts. PLoS One 15:e0233725 (2020). PubMed: 32470058
- Wadey RM et al. Inflammatory adipocyte-derived extracellular vesicles promote leukocyte attachment to vascular endothelial cells. Atherosclerosis 283:19-27 (2019). PubMed: 30771557
- Alghamdi TA et al. Histone H3 Serine 10 Phosphorylation Facilitates Endothelial Activation in Diabetic Kidney Disease. Diabetes 67:2668-2681 (2018). PubMed: 30213824
- He M et al. Treatment with BX471, a CC chemokine receptor 1 antagonist, attenuates systemic inflammatory response during sepsis. Am J Physiol Gastrointest Liver Physiol 292:G1173-80 (2007). PubMed: 17234893
- Lau HY & Bhatia M Effect of CP-96,345 on the expression of adhesion molecules in acute pancreatitis in mice. Am J Physiol Gastrointest Liver Physiol 292:G1283-92 (2007). PubMed: 17218475