Product nameAnti-CD62P antibody [AK4] - Low endotoxin, Azide free
See all CD62P primary antibodies
DescriptionMouse monoclonal [AK4] to CD62P - Low endotoxin, Azide free
Tested applicationsSuitable for: WB, IP, Functional Studies, ICC, Flow Cyt, Blockingmore details
Species reactivityReacts with: Human, Non human primates
Store at 2-8°C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles.
This product was changed from ascites to tissue culture supernatant on XXX (date). Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.
Storage instructionsShipped at 4°C. Please see notes section.
Storage bufferpH: 7.40
Constituent: 99% PBS
Concentration information loading...
PurityImmunogen affinity purified
Purification notesPurified from TCS
- Anti-CD62P antibody [AK4] (Phycoerythrin) (ab119104)
- Anti-CD62P antibody [AK4] (Allophycocyanin) (ab233255)
- Anti-CD62P antibody [AK4] (PE/Cy5.5 ®) (ab234221)
- Anti-CD62P antibody [AK4] (Biotin) (ab239233)
- Anti-CD62P antibody [AK4] (FITC) (ab239255)
- Anti-CD62P antibody [AK4] - BSA and Azide free (ab252266)
Our Abpromise guarantee covers the use of ab119848 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use at an assay dependent concentration. Predicted molecular weight: 90 kDa.|
|IP||Use at an assay dependent concentration.|
|Functional Studies||Use at an assay dependent concentration.|
|ICC||Use at an assay dependent concentration.|
|Flow Cyt||Use a concentration of 1.5 µg/ml.
ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
|Blocking||Use at an assay dependent concentration.|
FunctionCa(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.
Tissue specificityStored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.
Involvement in diseaseDefects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
Sequence similaritiesBelongs to the selectin/LECAM family.
Contains 1 C-type lectin domain.
Contains 1 EGF-like domain.
Contains 9 Sushi (CCP/SCR) domains.
- Information by UniProt
- Antigen CD62 antibody
- CD62 antibody
- CD62 antigen-like family member P antibody
This product has been referenced in:
- Ludwig RJ et al. Activated, not resting, platelets increase leukocyte rolling in murine skin utilizing a distinct set of adhesion molecules. J Invest Dermatol 122:830-6 (2004). Read more (PubMed: 15086572) »
- Dunlop LC et al. Characterization of GMP-140 (P-selectin) as a circulating plasma protein. J Exp Med 175:1147-50 (1992). Read more (PubMed: 1372646) »