Overview

  • Product name

    Anti-CD66a + CD66c + CD66d antibody [YTH71.3]
  • Description

    Rat monoclonal [YTH71.3] to CD66a + CD66c + CD66d
  • Host species

    Rat
  • Specificity

    ab128720 recognises Human CD66a + CD66c + CD66d. Clone YTH71.3 reacts with transfectants containing BGPa, NCA and CGM1a which are CEA subfamily members.
  • Tested applications

    Suitable for: IHC-Fr, Flow Cytmore details
  • Species reactivity

    Reacts with: Human, Rhesus monkey
  • Immunogen

    Human lymphocytes.

  • Positive control

    • Human peripheral blood granulocytes.
  • General notes

    Shelf life 18 months. Should this product contain a precipitate we recommend microcentrifugation before use. Storage in frost-free freezers is not recommended.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle. Store undiluted.
  • Storage buffer

    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Protein G purified
  • Clonality

    Monoclonal
  • Clone number

    YTH71.3
  • Myeloma

    Y3/Ag1.2.3
  • Isotype

    IgG2a
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab128720 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration.

Use 10µl of the suggested working dilution to label 106 cells in 100µl.

 

 

 

ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

 

Target

  • Function

    Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.
  • Tissue specificity

    CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney.
  • Sequence similarities

    Belongs to the immunoglobulin superfamily. CEA family.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Domain

    The cytosolic domain is involved in S100A9 interaction.
  • Post-translational
    modifications

    Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • BGP 1 antibody
    • BGPI antibody
    • Carcinoembryonic antigen CGM1 antibody
    • Carcinoembryonic antigen related cell adhesion molecule 1 antibody
    • Carcinoembryonic antigen related cell adhesion molecule 3 antibody
    • Carcinoembryonic antigen related cell adhesion molecule 6 antibody
    • Carcinoembryonic antigen-related cell adhesion molecule 3 antibody
    • CD66a antigen antibody
    • CD66c antigen antibody
    • CD66d antibody
    • CD66d antigen antibody
    • CEACAM1 antibody
    • Ceacam3 antibody
    • CEACAM6 antibody
    • CEAM3_HUMAN antibody
    see all

Images

  • ab128270 at 10µl/106 cells staining CD66a + CD66c + CD66d in Human peripheral blood granulocytes by Flow Cytometry.

References

ab128720 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab128720.
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