Overview

  • Product name

    Anti-CD79b antibody [AT107-2] (FITC)
    See all CD79b primary antibodies
  • Description

    Rat monoclonal [AT107-2] to CD79b (FITC)
  • Host species

    Rat
  • Conjugation

    FITC. Ex: 493nm, Em: 528nm
  • Specificity

    Recognises an intracellular region of human CD79b We have data to indicate that this antibody may not cross react with Chicken. However, this has not been conclusively tested and expression levels may vary in certain cell lines/tissues.
  • Tested applications

    Suitable for: Flow Cytmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Dog, Human, Pig
  • Immunogen

    Synthetic peptide corresponding to an intracellular region of human CD79b.

  • Positive control

    • Rat peripheral blood lymphocytes.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C.
  • Storage buffer

    Preservative: 0.09% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • Purity

    Protein G purified
  • Clonality

    Monoclonal
  • Clone number

    AT107-2
  • Myeloma

    NS1
  • Isotype

    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab33296 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
  • Application notes
    Flow Cyt: Use 10µl for 106 cells in 100µl.
    Note: Membrane permeabilisation is required for this application.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
    • Tissue specificity

      B-cells.
    • Involvement in disease

      Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6) [MIM:612692]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
    • Sequence similarities

      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
      Contains 1 ITAM domain.
    • Post-translational
      modifications

      Phosphorylated on tyrosine upon B-cell activation.
    • Cellular localization

      Cell membrane. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
    • Information by UniProt
    • Database links

    • Alternative names

      • AGM6 antibody
      • B cell antigen receptor complex associated protein beta chain antibody
      • B cell specific glycoprotein B29 antibody
      • B-cell antigen receptor complex-associated protein beta chain antibody
      • B-cell-specific glycoprotein B29 antibody
      • B29 antibody
      • B29/Ig-beta/CD79b antibody
      • CD 79b antibody
      • CD79b antibody
      • CD79b antigen (immunoglobulin associated beta) antibody
      • CD79b antigen antibody
      • CD79b molecule antibody
      • CD79b molecule immunoglobulin associated beta antibody
      • CD79b protein antibody
      • CD79B_HUMAN antibody
      • Ig beta antibody
      • Ig-beta antibody
      • IGB antibody
      • Igbeta antibody
      • Immunoglobulin associated B29 antibody
      • Immunoglobulin associated B29 protein antibody
      • Immunoglobulin associated beta antibody
      • Immunoglobulin associated protein antibody
      • Immunoglobulin-associated B29 protein antibody
      • MGC108607 antibody
      see all

    Images

    • Staining of rat peripheral blood lymphocytes with ab33296 after permeabilisation.

    References

    This product has been referenced in:

    • Sun Z  et al. Activated Wnt signaling induces myofibroblast differentiation of mesenchymal stem cells, contributing to pulmonary fibrosis. Int J Mol Med 33:1097-109 (2014). Flow Cyt ; Rat . Read more (PubMed: 24573542) »
    See 1 Publication for this product

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab33296.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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