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    cd80-antibody-mem-233-ab8239.pdf

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Immunology Adaptive Immunity B Cells CD
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Anti-CD80 antibody [MEM-233] (ab8239)

  • Datasheet
  • SDS
Submit a review Q&A (4)References (2)

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Key features and details

  • Mouse monoclonal [MEM-233] to CD80
  • Reacts with: Human
  • Isotype: IgG1

You may also be interested in

Protein
Product image
Recombinant Human CD80 protein (ab131745)
Secondary
Product image
Goat Anti-Mouse IgG H&L (HRP) (ab205719)

View more associated products

Overview

  • Product name

    Anti-CD80 antibody [MEM-233]
    See all CD80 primary antibodies
  • Description

    Mouse monoclonal [MEM-233] to CD80
  • Host species

    Mouse
  • Specificity

    CD80 antigen
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Fusion protein (Human).

  • General notes

    This product was changed from ascites to tissue culture supernatant on 24th January 2018. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.40
    Preservative: 0.097% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity

    Protein A purified
  • Purification notes

    Purified from TCS. Purity >95% by SDS-PAGE.
  • Clonality

    Monoclonal
  • Clone number

    MEM-233
  • Isotype

    IgG1
  • Light chain type

    unknown
  • Research areas

    • Immunology
    • Adaptive Immunity
    • B Cells
    • CD
    • Stem Cells
    • Hematopoietic Progenitors
    • Lymphoid
    • B Lymphocytic Lineage
    • Stem Cells
    • Hematopoietic Progenitors
    • Myeloid
    • Dendritic Cell Lineage
    • Stem Cells
    • Hematopoietic Progenitors
    • Myeloid
    • Monocytic Lineage

Associated products

  • Alternative Versions

    • FITC Anti-CD80 antibody [MEM-233] (ab18279)
    • PE/Cy5® Anti-CD80 antibody [MEM-233] (ab233572)
    • PE/Cy7® Anti-CD80 antibody [MEM-233] (ab234229)
    • Alexa Fluor® 700 Anti-CD80 antibody [MEM-233] (ab270668)
    • APC Anti-CD80 antibody [MEM-233] (ab27554)
    • PE Anti-CD80 antibody [MEM-233], prediluted (ab69778)
    • PerCP Anti-CD80 antibody [MEM-233] (ab82410)
  • Compatible Secondaries

    • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
    • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
  • Isotype control

    • Mouse IgG1, kappa monoclonal [15-6E10A7] - Isotype Control (ab170190)
  • Recombinant Protein

    • Recombinant Human CD80 protein (ab131745)

Target

  • Function

    Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.
  • Tissue specificity

    Expressed on activated B-cells, macrophages and dendritic cells.
  • Sequence similarities

    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Cellular localization

    Membrane.
  • Target information above from: UniProt accession P33681 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 941 Human
    • Omim: 112203 Human
    • SwissProt: P33681 Human
    • Unigene: 838 Human
    • Alternative names

      • Activation B7-1 antigen antibody
      • B lymphocyte activation antigen B7 antibody
      • B7 antibody
      • B7-1 antibody
      • B7-1 antigen antibody
      • B7.1 antibody
      • BB1 antibody
      • CD28 antigen ligand 1 antibody
      • CD28LG antibody
      • CD28LG1 antibody
      • CD80 antibody
      • CD80 antigen (CD28 antigen ligand 1, B7-1 antigen) antibody
      • CD80 antigen antibody
      • CD80 molecule antibody
      • CD80_HUMAN antibody
      • Costimulatory factor CD80 antibody
      • costimulatory molecule variant IgV-CD80 antibody
      • CTLA-4 counter-receptor B7.1 antibody
      • LAB7 antibody
      • T-lymphocyte activation antigen CD80 antibody
      see all

    Protocols

    • Flow cytometry protocols
    • Immunoprecipitation protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (2)

    Publishing research using ab8239? Please let us know so that we can cite the reference in this datasheet.

    ab8239 has been referenced in 2 publications.

    • Reiner A  et al. Motor, visual and emotional deficits in mice after closed-head mild traumatic brain injury are alleviated by the novel CB2 inverse agonist SMM-189. Int J Mol Sci 16:758-87 (2014). PubMed: 25561230
    • Hoffmann D  et al. Evaluation of twenty-one human adenovirus types and one infectivity-enhanced adenovirus for the treatment of malignant melanoma. J Invest Dermatol 128:988-98 (2008). PubMed: 17960177

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    1-4 of 4 Abreviews or Q&A

    Question

    Do you have any information on whether ab8239 reacts with any other B7 family molecules, besides CD80?

    Read More

    Abcam community

    Verified customer

    Asked on Jul 13 2004

    Answer

    Thank you for your enquiry. We regret to inform you that we do not have more information.

    Read More

    Abcam Scientific Support

    Answered on Jul 15 2004

    Question

    is this antibody working in anti-rat immunhistochemistry?

    Read More

    Abcam community

    Verified customer

    Asked on Sep 06 2002

    Answer

    This antibody has not been tested IHC on rat tissue, therefore we cannot guarantee results.

    Read More

    Abcam Scientific Support

    Answered on Sep 09 2002

    Question

    Have you an image of a membrane/Western blot that was revealed with this antibody and shows the profile of migration of CD80 ?

    Read More

    Abcam community

    Verified customer

    Asked on Jun 25 2002

    Answer

    We have no western blot images available for this antibody. However, if the antibody does not perform as stated on the datasheet, Abcam will offer a full refund or a replacement.

    Read More

    Abcam Scientific Support

    Answered on Jun 26 2002

    Question

    Does this antibody cross react with the dog.

    Read More

    Abcam community

    Verified customer

    Asked on Dec 07 2001

    Answer

    This antibody has not yet been tested on dog

    Read More

    Abcam Scientific Support

    Answered on Dec 07 2001

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    For licensing inquiries, please contact partnerships@abcam.com

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