Overview

  • Product name

    CDC, lipoxygenase inhibitor
  • Description

    Potent, selective lipoxygenase inhibitor
  • Biological description

    Potent, selective 12-Lipoxygenase (12-LO) inhibitor (IC50 = 63 nM). Also inhibits 15-LO and 5-LO (IC50 values are 3.33 and 1.89 μM respectively). Active in vivo.
  • Purity

    > 98%
  • CAS Number

    132465-11-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Cinnamyl-3,4-dihydroxy-α-cyanocinnamate
  • Molecular weight

    321.30
  • Molecular formula

    C19H15NO4
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 10 mM and in ethanol to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    N#C\C(=C\c1cc(O)c(O)cc1)C(=O)OC\C=C\c2ccccc2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Pergola C  et al. Cinnamyl-3,4-dihydroxy-a-cyanocinnamate is a potent inhibitor of 5-lipoxygenase. J Pharmacol Exp Ther 338:205-13 (2011). Read more (PubMed: 21447614) »
  • Gong YZ  et al. Cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate and nordihydroguaiaretic acid inhibit human Kv1.5 currents independently of lipoxygenase. Eur J Pharmacol 600:18-25 (2008). Read more (PubMed: 18930721) »
  • Takizawa H  et al. Prostaglandin I2 contributes to the vasodepressor effect of baicalein in hypertensive rats. Hypertension 31:866-71 (1998). Read more (PubMed: 9495274) »
  • Cho H  et al. Novel caffeic acid derivatives: extremely potent inhibitors of 12-lipoxygenase. J Med Chem 34:1503-5 (1991). Read more (PubMed: 2016727) »
See 1 Publication for this product

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