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    cdc13-antibody-6f112-ab10873.pdf

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Epigenetics and Nuclear Signaling Chromosome Structure Telomeres
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Anti-Cdc13 antibody [6F11/2] (ab10873)

  • Datasheet
  • SDS
Submit a review Submit a question References (5)

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Key features and details

  • Mouse monoclonal [6F11/2] to Cdc13
  • Suitable for: WB, IP
  • Isotype: IgG2a

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Overview

  • Product name

    Anti-Cdc13 antibody [6F11/2]
  • Description

    Mouse monoclonal [6F11/2] to Cdc13
  • Host species

    Mouse
  • Tested applications

    Suitable for: WB, IPmore details
  • Immunogen

    Full length native protein (purified).

  • General notes


    Cdc13 is a fission yeast (S. pombe) B-type M-phase cyclin. Cdc13 binds to Cdk1 (cdc2), and the resulting Cdk1-Cdc13 complex controls the G2/M transition of the cell cycle. 6F11/2 can be used for detecting Cdc13 and associated Cdk1 kinase activation.

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    Constituent: PBS
  • Concentration information loading...
  • Purity

    Protein A purified
  • Primary antibody notes

    Cdc13 is a fission yeast (S. pombe) B-type M-phase cyclin. Cdc13 binds to Cdk1 (cdc2), and the resulting Cdk1-Cdc13 complex controls the G2/M transition of the cell cycle. 6F11/2 can be used for detecting Cdc13 and associated Cdk1 kinase activation.
  • Clonality

    Monoclonal
  • Clone number

    6F11/2
  • Myeloma

    Sp2
  • Isotype

    IgG2a
  • Research areas

    • Epigenetics and Nuclear Signaling
    • Chromosome Structure
    • Telomeres

Associated products

  • Compatible Secondaries

    • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
    • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
  • Isotype control

    • Mouse IgG2a, kappa monoclonal [MG2a-53] - Isotype control (ab18415)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab10873 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
Use at an assay dependent dilution. Predicted molecular weight: 48 kDa.
IP
Use at an assay dependent dilution.
Notes
WB
Use at an assay dependent dilution. Predicted molecular weight: 48 kDa.
IP
Use at an assay dependent dilution.

Target

  • Alternative names

    • CDC 13 antibody
    • G2/mitotic specific cyclin antibody

Protocols

  • Western blot protocols
  • Immunoprecipitation protocols

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (5)

Publishing research using ab10873? Please let us know so that we can cite the reference in this datasheet.

ab10873 has been referenced in 5 publications.

  • Rothe C  et al. A checkpoint-independent mechanism delays entry into mitosis after UV irradiation. J Cell Sci 130:4028-4037 (2017). PubMed: 29046339
  • Uchiyama M  et al. The Protein Level of Rev1, a TLS Polymerase in Fission Yeast, Is Strictly Regulated during the Cell Cycle and after DNA Damage. PLoS One 10:e0130000 (2015). PubMed: 26147350
  • Bandyopadhyay S  et al. The basic leucine zipper domain transcription factor Atf1 directly controls Cdc13 expression and regulates mitotic entry independently of Wee1 and Cdc25 in Schizosaccharomyces pombe. Eukaryot Cell 13:813-21 (2014). Schizosaccharomyces pombe . PubMed: 24728197
  • Okuzaki D  et al. Spo5 phosphorylation is essential for its own timely degradation and for successful meiosis in Schizosaccharomyces pombe. Cell Cycle 9: (2010). WB ; Schizosaccharomyces pombe . PubMed: 20855961
  • Decottignies A  et al. In vivo localisation of fission yeast cyclin-dependent kinase cdc2p and cyclin B cdc13p during mitosis and meiosis. J Cell Sci 114:2627-40 (2001). PubMed: 11683390

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