Overview

  • Product name
    Anti-Cdc14A antibody - C-terminal
  • Description
    Rabbit polyclonal to Cdc14A - C-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Cdc14A aa 472-500 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q9UNH5

  • Positive control
    • A549 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab172951 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 67 kDa.

Target

  • Relevance
    Overproduction of hCdc14A leads to progressive cell death, accompanied by accumulation of pre-G1 DNA fragments and gradual elimination of cells at the G2/M transition. In 50% of the mitotic cells, multipolar mitotic spindles and misaggregated chromosomes are found. hCdc14A localizes to the centrosomes at the cell-cycle interphase stage. When the cell enters mitosis, this localization disappears suggesting that hCdc14A dissociates from the centrosomes at the G2/M transition. hCdc14A localizes to interphase centrosomes, but not to mitotic centrosomes, while hCdc14B localizes to the interphase nucleolus. Thus each isoform regulates separate cell cycle events. Cdc14A may affect cell cycle progression by its ability to dephosphorylate p53 at Ser315. This phosphatase activity is mediated by the interaction between the N-terminus of hCdc14A and the C-terminus of p53.
  • Cellular localization
    Cytoplasmic, Cytoskeleton, Nuclear.
  • Database links
  • Alternative names
    • CDC 10 antibody
    • Cdc 14 antibody
    • Cdc 14A antibody
    • Cdc 14A1 antibody
    • Cdc 14A2 antibody
    • CDC10 (cell division cycle 10, S. cerevisiae, homolog) antibody
    • CDC10 antibody
    • Cdc14 antibody
    • CDC14 cell division cycle 14 homolog A antibody
    • CDC14 homolog A antibody
    • Cdc14A1 antibody
    • Cdc14A2 antibody
    • Cell division cycle 14 homolog A antibody
    • Cell division cycle 14, S. cerevisiae, homolog A antibody
    • Cell division cycle 14A antibody
    • Dual specificity protein phosphatase CDC 14A antibody
    • Dual specificity protein phosphatase CDC14A antibody
    • hCDC 14 antibody
    • hCDC14 antibody
    • OTTHUMP00000012653 antibody
    • OTTHUMP00000012654 antibody
    • OTTHUMP00000012655 antibody
    see all

Images

  • Anti-Cdc14A antibody - C-terminal (ab172951) at 1/100 dilution + A549 cell lysate at 35 µg

    Predicted band size: 67 kDa

References

ab172951 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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