Overview

  • Product name

    Anti-Cdc14B antibody
  • Description

    Rabbit polyclonal to Cdc14B
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human Cdc14B aa 94-122 conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Sequence:

    LAMVYRYCCKINKKLKSITMLRKKIVHFT


    Database link: O60729

  • Positive control

    • Mouse embryo tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab203675 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.

(or 1/50 - 1/200 if using a fluorescent secondary antibody)

WB 1/100 - 1/1000. Predicted molecular weight: 57 kDa.

Target

  • Function

    Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.
  • Sequence similarities

    Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
  • Domain

    Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.
  • Cellular localization

    Nucleus > nucleolus. Nucleus > nucleoplasm. Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1.
  • Information by UniProt
  • Database links

  • Alternative names

    • CC14B_HUMAN antibody
    • Cdc 14B antibody
    • Cdc 14B1 antibody
    • Cdc 14B2 antibody
    • CDC 14B3 antibody
    • CDC14 cell division cycle 14 homolog B antibody
    • CDC14 homolog B antibody
    • Cdc14b antibody
    • Cdc14B1 antibody
    • Cdc14B2 antibody
    • CDC14B3 antibody
    • Cell division cycle 14 homolog B antibody
    • Dual specificity protein phosphatase CDC14B antibody
    • hCDC 14B antibody
    • hCDC14B antibody
    • OTTHUMP00000063774 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed paraffin-embedded Mouse embryo tissue labeling Cdc14B with ab203675 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

References

ab203675 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab203675.
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