Overview

  • Product name

  • Description

    Rabbit polyclonal to Cdc25C
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Chimpanzee, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide corresponding to a region between residue 150 and 200 of human Cdc25C (NP_001781.2)

  • Positive control

    • human seminoma, human breast carcinoma, mouse teratoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab84485 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.

Target

  • Function

    Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDK1 and activate its kinase activity.
  • Sequence similarities

    Belongs to the MPI phosphatase family.
    Contains 1 rhodanese domain.
  • Developmental stage

    Expressed predominantly in G2 phase.
  • Post-translational
    modifications

    Phosphorylated by CHK1 on Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase. Phosphorylated by PLK4.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • CDC 25 antibody
    • Cdc 25C antibody
    • CDC25 antibody
    • CDC25C antibody
    • Cell division cycle 25 homolog C antibody
    • Cell division cycle 25C antibody
    • Cell division cycle 25C protein antibody
    • Dual specificity phosphatase Cdc25C antibody
    • M phase inducer phosphatase 3 antibody
    • M-phase inducer phosphatase 3 antibody
    • Mitosis inducer CDC25 antibody
    • MPIP3 antibody
    • MPIP3_HUMAN antibody
    • Phosphotyrosine phosphatase antibody
    • PPP1R60 antibody
    • protein phosphatase 1, regulatory subunit 60 antibody
    see all

Images

  • ab84485 at a dilution of 1/250 staining a formalin-fixed, paraffin-embedded section of human seminoma.
    Detection: DAB staining.
  • ab84485 at a dilution of 1/250 staining a formalin-fixed, paraffin-embedded section of human breast carcinoma.
    Detection: DAB staining.
  • ab84485 at a dilution of 1/250 staining formalin-fixed, paraffin-embedded section of mouse teratoma.
    Detection: DAB staining.

References

This product has been referenced in:

  • Shirazi Fard S  et al. Heterogenic final cell cycle by chicken retinal Lim1 horizontal progenitor cells leads to heteroploid cells with a remaining replicated genome. PLoS One 8:e59133 (2013). IHC-P . Read more (PubMed: 23527113) »
See 1 Publication for this product

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