Cdc25C peptide (ab204870)

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Description

Associated products

Specifications

Our Abpromise guarantee covers the use of ab204870 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    HPLC

  • Form

    Liquid

  • Additional notes

    ab204870 (Cdc25C peptide) can be utilized as a substrate for the active protein kinase ab105126 (Active human GRK1 full length protein)

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names

    • CDC 25
    • Cdc 25C
    • CDC25
    • CDC25C
    • Cell division cycle 25 homolog C
    • Cell division cycle 25C
    • Cell division cycle 25C protein
    • Dual specificity phosphatase Cdc25C
    • M phase inducer phosphatase 3
    • M-phase inducer phosphatase 3
    • Mitosis inducer CDC25
    • MPIP3
    • MPIP3_HUMAN
    • Phosphotyrosine phosphatase
    • PPP1R60
    • protein phosphatase 1, regulatory subunit 60
    see all

  • Function

    Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDK1 and activate its kinase activity.

  • Sequence similarities

    Belongs to the MPI phosphatase family.
    Contains 1 rhodanese domain.

  • Developmental stage

    Expressed predominantly in G2 phase.

  • Post-translational
    modifications

    Phosphorylated by CHK1 on Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase. Phosphorylated by PLK4.

  • Cellular localization

    Nucleus.
  • Information by UniProt

References

ab204870 has not yet been referenced specifically in any publications.

Publishing research using ab204870? Please let us know so that we can cite the reference in this datasheet.

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