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    cdc6-antibody-cdc6-9h85-ab20150.pdf

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Epigenetics and Nuclear Signaling DNA / RNA DNA Synthesis Other
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Anti-Cdc6 antibody [Cdc6 9H8/5] (ab20150)

  • Datasheet
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Key features and details

  • Mouse monoclonal [Cdc6 9H8/5] to Cdc6
  • Reacts with: Saccharomyces cerevisiae
  • Isotype: IgG1

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Overview

  • Product name

    Anti-Cdc6 antibody [Cdc6 9H8/5]
    See all Cdc6 primary antibodies
  • Description

    Mouse monoclonal [Cdc6 9H8/5] to Cdc6
  • Host species

    Mouse
  • Species reactivity

    Reacts with: Saccharomyces cerevisiae
  • Immunogen

    Full length protein corresponding to Saccharomyces cerevisiae Cdc6.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    Constituent: PBS
  • Concentration information loading...
  • Purity

    Protein A/G purified
  • Clonality

    Monoclonal
  • Clone number

    Cdc6 9H8/5
  • Myeloma

    unknown
  • Isotype

    IgG1
  • Light chain type

    unknown
  • Research areas

    • Epigenetics and Nuclear Signaling
    • DNA / RNA
    • DNA Synthesis
    • Other
    • Cell Biology
    • Cell Cycle
    • Cell Division
    • Other cell division antibodies

Associated products

  • Compatible Secondaries

    • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
    • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
  • Isotype control

    • Mouse IgG1, kappa monoclonal [15-6E10A7] - Isotype Control (ab170190)

Target

  • Function

    Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
  • Sequence similarities

    Belongs to the CDC6/cdc18 family.
  • Cellular localization

    Nucleus. Cytoplasm. The protein is nuclear in G1 and cytoplasmic in S-phase cells.
  • Target information above from: UniProt accession Q99741 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Alternative names

    • Cdc 18L antibody
    • Cdc 6 antibody
    • CDC18 (cell division cycle 18, S.pombe, homolog) like antibody
    • CDC18 (S.pombe) antibody
    • Cdc18 related protein antibody
    • CDC18(S.pombe) antibody
    • Cdc18-related protein antibody
    • Cdc18L antibody
    • cdc6 antibody
    • CDC6 cell division cycle 6 homolog antibody
    • CDC6 related protein antibody
    • CDC6-related protein antibody
    • CDC6_HUMAN antibody
    • Cdc6p antibody
    • CELL CYCLE CONTROLLER CDC6 antibody
    • Cell division control protein 6 antibody
    • Cell division control protein 6 homolog antibody
    • Cell division cycle 6 homolog (S. cerevisiae) antibody
    • Cell division cycle 6 homolog antibody
    • Cell division cycle 6, S. cerevisiae, homolog of antibody
    • HsCDC 6 antibody
    • HsCDC18 antibody
    • HsCDC6 antibody
    • p62 antibody
    • p62(cdc 6) antibody
    • p62(cdc6) antibody
    see all

Protocols

  • Western blot protocols
  • Immunoprecipitation protocols

Click here to view the general protocols

Datasheets and documents

    • Datasheet
  • References (6)

    Publishing research using ab20150? Please let us know so that we can cite the reference in this datasheet.

    ab20150 has been referenced in 6 publications.

    • Evrin C  et al. In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization. Nucleic Acids Res 41:3162-72 (2013). WB . PubMed: 23376927
    • Evrin C  et al. The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation. Nucleic Acids Res N/A:N/A (2013). IP . PubMed: 24234446
    • Ikui AE  et al. A yeast GSK-3 kinase Mck1 promotes Cdc6 degradation to inhibit DNA re-replication. PLoS Genet 8:e1003099 (2012). WB . PubMed: 23236290
    • Zhang JY  et al. Tumor necrosis factor receptor 1/c-Jun-NH2-kinase signaling promotes human neoplasia. Cancer Res 67:3827-34 (2007). WB . PubMed: 17440097
    • Perkins G  et al. Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis. EMBO J 20:4836-45 (2001). PubMed: 11532947
    • Donovan S  et al. Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. Proc Natl Acad Sci U S A 94:5611-6 (1997). PubMed: 9159120

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