Product nameCDDO imidazolide, Fatty acid synthesis inhibitor
DescriptionFatty acid synthesis inhibitor.
- 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid imidazolide
Synthetic triterpenoid. Inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells. Highly active in suppressing cellular proliferation of human leukemia and breast cancer cell lines as well as being an effective therapeutic agent in the treatment of other types of cancers. Potent inducer of Heme Oxygenase-1 and Nrf2/ARE Signaling.
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Hughes DT et al. The synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells. Cancer Invest 26:118-27 (2008). Read more (PubMed: 18259941) »
- Samudio I et al. 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer. J Biol Chem 280:36273-82 (2005). Read more (PubMed: 16118208) »
- Liby K et al. The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling. Cancer Res 65:4789-98 (2005). Read more (PubMed: 15930299) »
- Place AE et al. The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo. Clin Cancer Res 9:2798-806 (2003). Read more (PubMed: 12855660) »