CDDO methyl ester, Synthetic triterpenoid (ab143795)

Overview

  • Product name

    CDDO methyl ester, Synthetic triterpenoid
  • Description

    Synthetic triterpenoid.
  • Alternative names

    • 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid Methyl Ester
    • Bardoxolone Methyl
    • CDDO-Me
    • Methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate
    • NSC 713200
    • RTA 402
    see all
  • Biological description

    Synthetic triterpenoid that inhibits IκBα kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor κB-regulated gene products in human leukemic cells. Novel therapeutic agent in the treatment of acute myeloid leukemia and pancreatic cancer as well as other forms of cancer.

  • CAS Number

    218600-53-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester
  • Molecular weight

    505.69
  • Molecular formula

    C32H43NO4
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Gao X  et al. Role of reactive oxygen species (ROS) in CDDO-Me-mediated growth inhibition and apoptosis in colorectal cancer cells. J Exp Ther Oncol 9:119-27 (2011). Read more (PubMed: 21699019) »
  • Deeb D  et al. CDDO-Me: A Novel Synthetic Triterpenoid for the Treatment of Pancreatic Cancer. Cancers (Basel) 2:1779-93 (2010). Read more (PubMed: 21799944) »
  • Shishodia S  et al. A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells. Clin Cancer Res 12:1828-38 (2006). Read more (PubMed: 16551868) »
  • Konopleva M  et al. The novel triterpenoid CDDO-Me suppresses MAPK pathways and promotes p38 activation in acute myeloid leukemia cells. Leukemia 19:1350-4 (2005). Read more (PubMed: 15931262) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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