Validated using a knockout cell line

Recombinant Anti-Cdk2 antibody [E304] (ab32147)

Knockout Tested Rabbit recombinant monoclonal Cdk2 antibody [E304]. Validated in WB, IP, IHC, Flow Cyt, ICC/IF and tested in Mouse, Rat, Human. Cited in 46 publication(s).

Publishing research using ab32147? Please let us know so that we can cite the reference in this datasheet.

ab32147 has been referenced in 51 publications.

  • Kohama Y  et al. Regulation of the stability and activity of CDC25A and CDC25B by protein phosphatase PP2A and 14-3-3 binding. Cell Signal 54:10-16 (2019). PubMed: 30468767
  • Deng J  et al. N-acetylcysteine decreases malignant characteristics of glioblastoma cells by inhibiting Notch2 signaling. J Exp Clin Cancer Res 38:2 (2019). PubMed: 30606241
  • Xu C & Zheng J siRNA against TSG101 reduces proliferation and induces G0/G1 arrest in renal cell carcinoma - involvement of c-myc, cyclin E1, and CDK2. Cell Mol Biol Lett 24:7 (2019). PubMed: 30675171
  • Chen Y  et al. Lost expression of cell adhesion molecule 1 is associated with bladder cancer progression and recurrence and its overexpression inhibited tumor cell malignant behaviors. Oncol Lett 17:2047-2056 (2019). PubMed: 30719104
  • Xu C  et al. Coupling function of cyclin-dependent kinase 2 and Septin2 in the promotion of hepatocellular carcinoma. Cancer Sci 110:540-549 (2019). PubMed: 30444001
  • Fang G  et al. LncRNA MRAK048635_P1 is critical for vascular smooth muscle cell function and phenotypic switching in essential hypertension. Biosci Rep 39:N/A (2019). PubMed: 30833363
  • Zhao B  et al. Peiminine Inhibits Glioblastoma in Vitro and in Vivo Through Cell Cycle Arrest and Autophagic Flux Blocking. Cell Physiol Biochem 51:1566-1583 (2018). PubMed: 30497066
  • Arosh JA & Banu SK Dual inhibition of ERK1/2 and AKT pathways is required to suppress the growth and survival of endometriotic cells and lesions. Mol Cell Endocrinol N/A:N/A (2018). PubMed: 30578826
  • Luo J  et al. High Glucose-Induced ROS Production Stimulates Proliferation of Pancreatic Cancer via Inactivating the JNK Pathway. Oxid Med Cell Longev 2018:6917206 (2018). PubMed: 30584464
  • Yu X  et al. lncRNA LINC01296 regulates the proliferation, metastasis and cell cycle of osteosarcoma through cyclin D1. Oncol Rep 40:2507-2514 (2018). PubMed: 30226542
  • Malcov-Brog H  et al. UV-Protection Timer Controls Linkage between Stress and Pigmentation Skin Protection Systems. Mol Cell 72:444-456.e7 (2018). PubMed: 30401431
  • Shen L  et al. NDRG2 facilitates colorectal cancer differentiation through the regulation of Skp2-p21/p27 axis. Oncogene 37:1759-1774 (2018). WB ; Mouse . PubMed: 29343851
  • Ma Y  et al. High expression of PRPS1 induces an anti-apoptotic effect in B-ALL cell lines and predicts an adverse prognosis in Chinese children with B-ALL. Oncol Lett 15:4314-4322 (2018). PubMed: 29541198
  • Ye C  et al. High glucose induces the proliferation of prostatic cells via downregulating MRE11. Int J Mol Med 41:3105-3114 (2018). PubMed: 29532862
  • Wang L  et al. TIPE-2 suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3-kinase/AKT signaling pathway. Mol Med Rep 17:7017-7026 (2018). PubMed: 29568863
  • Xu L  et al. Morphological adaptation of sheep's rumen epithelium to high-grain diet entails alteration in the expression of genes involved in cell cycle regulation, cell proliferation and apoptosis. J Anim Sci Biotechnol 9:32 (2018). PubMed: 29686866
  • Zhou YJ  et al. Anti-Cervical Cancer Role of Matrine, Oxymatrine and Sophora Flavescens Alkaloid Gels and its Mechanism. J Cancer 9:1357-1364 (2018). PubMed: 29721044
  • Li W  et al. Sirtuin7 has an oncogenic potential via promoting the growth of cholangiocarcinoma cells. Biomed Pharmacother 100:257-266 (2018). WB . PubMed: 29438839
  • Tian L  et al. Calotropin regulates the apoptosis of non-small cell cancer by regulating the cytotoxic T-lymphocyte associated antigen 4-mediated TGF-ß/ERK signaling pathway. Mol Med Rep 17:7683-7691 (2018). PubMed: 29620207
  • Li X  et al. Tunicamycin inhibits progression of glioma cells through downregulation of the MEG-3-regulated wnt/ß-catenin signaling pathway. Oncol Lett 15:8470-8476 (2018). PubMed: 29805584
  • Gu H  et al. Highly expressed histone deacetylase 5 promotes the growth of hepatocellular carcinoma cells by inhibiting the TAp63-maspin pathway. Am J Cancer Res 8:462-475 (2018). WB ; Human . PubMed: 29637001
  • Liu X Up-regulation of miR-20a by HPV16 E6 exerts growth-promoting effects by targeting PDCD6 in cervical carcinoma cells. Biomed Pharmacother 102:996-1002 (2018). WB . PubMed: 29710555
  • Jin LZ  et al. Silencing SUMO2 promotes protection against degradation and apoptosis of nucleus pulposus cells through p53 signaling pathway in intervertebral disc degeneration. Biosci Rep 38:N/A (2018). PubMed: 29700214
  • Tang Z  et al. CDK2 positively regulates aerobic glycolysis by suppressing SIRT5 in gastric cancer. Cancer Sci 109:2590-2598 (2018). PubMed: 29896817
  • Wang T & Ha M Silencing ARHGAP9 correlates with the risk of breast cancer and inhibits the proliferation, migration, and invasion of breast cancer. J Cell Biochem 119:7747-7756 (2018). PubMed: 29905031
  • Li BS  et al. Camptothecin inhibits the progression of NPC by regulating TGF-ß-induced activation of the PI3K/AKT signaling pathway. Oncol Lett 16:552-558 (2018). PubMed: 29963130
  • Yu W  et al. Astragaloside IV reduces the hypoxia-induced injury in PC-12 cells by inhibiting expression of miR-124. Biomed Pharmacother 106:419-425 (2018). PubMed: 29990829
  • Xin J  et al. miR-204 functions as a tumor suppressor gene, at least partly by suppressing CYP27A1 in glioblastoma. Oncol Lett 16:1439-1448 (2018). PubMed: 30008822
  • Gu Y  et al. SET7/9 promotes hepatocellular carcinoma progression through regulation of E2F1. Oncol Rep 40:1863-1874 (2018). PubMed: 30106440
  • Ji X  et al. PolyC-binding proteins enhance expression of the CDK2 cell cycle regulatory protein via alternative splicing. Nucleic Acids Res 46:2030-2044 (2018). PubMed: 29253178
  • You S  et al. Tunicamycin inhibits colon carcinoma growth and aggressiveness via modulation of the ERK-JNK-mediated AKT/mTOR signaling pathway. Mol Med Rep 17:4203-4212 (2018). PubMed: 29344654
  • Liu W  et al. Dexamethasone-induced production of reactive oxygen species promotes apoptosis via endoplasmic reticulum stress and autophagy in MC3T3-E1 cells. Int J Mol Med 41:2028-2036 (2018). PubMed: 29393368
  • Zhou Z  et al. Inhibiting proliferation and migration of lung cancer using small interfering RNA targeting on Aldo-keto reductase family 1 member B10. Mol Med Rep 17:2153-2160 (2018). PubMed: 29207124
  • Hu Q  et al. Knockdown of SIRT1 Suppresses Bladder Cancer Cell Proliferation and Migration and Induces Cell Cycle Arrest and Antioxidant Response through FOXO3a-Mediated Pathways. Biomed Res Int 2017:3781904 (2017). PubMed: 29147649
  • Lu H  et al. Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair. Nat Commun 8:2039 (2017). WB . PubMed: 29229926
  • Chen S  et al. Long non-coding RNA PTENP1 inhibits proliferation and migration of breast cancer cells via AKT and MAPK signaling pathways. Oncol Lett 14:4659-4662 (2017). WB ; Human . PubMed: 29085464
  • Gao T  et al. LncRNA HSP90AA1-IT1 promotes gliomas by targeting miR-885-5p-CDK2 pathway. Oncotarget 8:75284-75297 (2017). PubMed: 29088865
  • Liu W  et al. Overexpression of non-SMC condensin I complex subunit G serves as a promising prognostic marker and therapeutic target for hepatocellular carcinoma. Int J Mol Med 40:731-738 (2017). PubMed: 28737823
  • Yu P  et al. Androgen-independent LNCaP cells are a subline of LNCaP cells with a more aggressive phenotype and androgen suppresses their growth by inducing cell cycle arrest at the G1 phase. Int J Mol Med 40:1426-1434 (2017). PubMed: 28901378
  • Zhang YY & Feng HM MEG3 Suppresses Human Pancreatic Neuroendocrine Tumor Cells Growth and Metastasis by Down-Regulation of Mir-183. Cell Physiol Biochem 44:345-356 (2017). PubMed: 29132136
  • Tian LQ  et al. MicroRNA-197 inhibits cell proliferation by targeting GAB2 in glioblastoma. Mol Med Rep N/A:N/A (2016). PubMed: 27035789
  • Hu R  et al. TMEM45B, up-regulated in human lung cancer, enhances tumorigenicity of lung cancer cells. Tumour Biol 37:12181-12191 (2016). Human . PubMed: 27225290
  • Wang J  et al. Cyclin-Dependent Kinase 2 Promotes Tumor Proliferation and Induces Radio Resistance in Glioblastoma. Transl Oncol 9:548-556 (2016). IHC-P . PubMed: 27863310
  • Chen JL  et al. Suppression of SIK1 by miR-141 in human ovarian cancer cell lines and tissues. Int J Mol Med 37:1601-10 (2016). PubMed: 27081781
  • Liao YX  et al. Silencing of RTKN2 by siRNA suppresses proliferation, and induces G1 arrest and apoptosis in human bladder cancer cells. Mol Med Rep 13:4872-8 (2016). PubMed: 27082503
  • Xiang Y  et al. miR-483 is Down-Regulated in Polycystic Ovarian Syndrome and Inhibits KGN Cell Proliferation via Targeting Insulin-Like Growth Factor 1 (IGF1). Med Sci Monit 22:3383-3393 (2016). PubMed: 27662007
  • Gao K  et al. HDGF-related protein-2 (HRP-2) acts as an oncogene to promote cell growth in hepatocellular carcinoma. Biochem Biophys Res Commun 458:849-55 (2015). WB ; Human . PubMed: 25689719
  • Lan Z  et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med 36:904-10 (2015). PubMed: 26201988
  • Perry MC  et al. ERBB2 deficiency alters an E2F-1-dependent adaptive stress response and leads to cardiac dysfunction. Mol Cell Biol 34:4232-43 (2014). WB ; Mouse, Human . PubMed: 25246633
  • Le TD  et al. Capsaicin-induced apoptosis of FaDu human pharyngeal squamous carcinoma cells. Yonsei Med J 53:834-41 (2012). WB . PubMed: 22665354
  • Liu D  et al. Lewis y Regulate Cell Cycle Related Factors in Ovarian Carcinoma Cell RMG-I in Vitro via ERK and Akt Signaling Pathways. Int J Mol Sci 13:828-39 (2012). WB . PubMed: 22312289

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