Anti-Cdk2 (phospho T160) antibody (ab194868)
Key features and details
- Rabbit polyclonal to Cdk2 (phospho T160)
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Cdk2 (phospho T160) antibody
See all CDK2 primary antibodies -
Description
Rabbit polyclonal to Cdk2 (phospho T160) -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human Cdk2 (phospho T160).
Database link: P24941 -
Positive control
- UV treated HeLa cell extracts; Human breast carcinoma tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab194868 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/50 - 1/100.
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WB |
1/500 - 1/2000. Predicted molecular weight: 34 kDa.
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Notes |
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IHC-P
1/50 - 1/100. |
WB
1/500 - 1/2000. Predicted molecular weight: 34 kDa. |
Target
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Function
Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2. -
Sequence similarities
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Contains 1 protein kinase domain. - Information by UniProt
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Database links
- Entrez Gene: 1017 Human
- Omim: 116953 Human
- SwissProt: P24941 Human
- Unigene: 19192 Human
- Unigene: 689624 Human
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Alternative names
- Cdc2 related protein kinase antibody
- cdc2-related protein kinase antibody
- CDC28 antibody
see all
Images
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All lanes : Anti-Cdk2 (phospho T160) antibody (ab194868) at 1/500 dilution
Lane 1 : Untreated HeLa cell extract
Lane 2 : UV treated HeLa cell extract
Predicted band size: 34 kDa -
Immunohistochemical analysis of paraffin-embedded Human breast carcinoma tissue labeling Cdk2 (phospho T160) with ab194868 at 1/50 dilution.
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (8)
ab194868 has been referenced in 8 publications.
- Kim MJ et al. The p53-Driven Anticancer Effect of Ribes fasciculatum Extract on AGS Gastric Cancer Cells. Life (Basel) 12:N/A (2022). PubMed: 35207590
- Shen L et al. Involvement of the oncogenic small nucleolar RNA SNORA24 in regulation of p53 stability in colorectal cancer. Cell Biol Toxicol N/A:N/A (2022). PubMed: 36087186
- Zheng Q et al. Hsa_circ_0000520 overexpression increases CDK2 expression via miR-1296 to facilitate cervical cancer cell proliferation. J Transl Med 19:314 (2021). PubMed: 34284793
- Xu L et al. Accumulated cytotoxicity of CDK inhibitor dinaciclib with first-line chemotherapy drugs in salivary adenoid cystic carcinoma cells. Odontology 108:300-311 (2020). PubMed: 31529315
- Wang G et al. Tethering of Telomeres to the Nuclear Envelope Is Mediated by SUN1-MAJIN and Possibly Promoted by SPDYA-CDK2 During Meiosis. Front Cell Dev Biol 8:845 (2020). PubMed: 33015044
- Yamamura M et al. The cyclin-dependent kinase pathway involving CDK1 is a potential therapeutic target for cholangiocarcinoma. Oncol Rep 43:306-317 (2020). PubMed: 31746435
- Baharani A et al. A Progressive Loss of phosphoSer138-Profilin Aligns with Symptomatic Course in the R6/2 Mouse Model of Huntington's Disease: Possible Sex-Dependent Signaling. Cell Mol Neurobiol N/A:N/A (2020). PubMed: 33108594
- Xia P et al. Inhibition of cyclin-dependent kinase 2 protects against doxorubicin-induced cardiomyocyte apoptosis and cardiomyopathy. J Biol Chem 293:19672-19685 (2018). PubMed: 30361442