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    cdx2-antibody-ab70458.pdf

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Stem Cells Lineage Markers Endoderm
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Anti-CDX2 antibody (ab70458)

  • Datasheet
  • SDS
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CDX2 antibody (ab70458)

    Key features and details

    • Rabbit polyclonal to CDX2
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

    You may also be interested in

    Protein
    Product image
    Recombinant Human CDX2 protein (ab114247)
    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

    View more associated products

    Overview

    • Product name

      Anti-CDX2 antibody
      See all CDX2 primary antibodies
    • Description

      Rabbit polyclonal to CDX2
    • Host species

      Rabbit
    • Tested Applications & Species

      Application Species
      IHC-P
      Human
      See all applications and species data
    • Immunogen

      Synthetic peptide corresponding to a region between residues 250 and 300 of Human CDX2 (according to NP_001256.1)

    • Positive control

      • 293T whole cell lysates.
    • General notes

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
    • Storage buffer

      pH: 7
      Preservative: 0.09% Sodium azide
      Constituents: 1.815% Tris, 1.764% Sodium citrate, 0.021% PBS
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Stem Cells
      • Lineage Markers
      • Endoderm
      • Epigenetics and Nuclear Signaling
      • Transcription
      • Transcription Factors
      • Developmental Biology
      • Lineage specification
      • Endoderm
      • Developmental Biology
      • Lineage specification
      • Trophectoderm

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Recombinant Protein

      • Recombinant Human CDX2 protein (ab114247)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab70458 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    Application Species
    IHC-P
    Human
    All applications
    Cow
    Chimpanzee
    Gorilla
    Orangutan
    Bat
    Application Abreviews Notes
    IHC-P
    1/500 - 1/2000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
    Notes
    IHC-P
    1/500 - 1/2000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

    Target

    • Function

      Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.
    • Sequence similarities

      Belongs to the Caudal homeobox family.
      Contains 1 homeobox DNA-binding domain.
    • Post-translational
      modifications

      Phosphorylation of Ser-60 mediates the transactivation capacity.
    • Cellular localization

      Nucleus.
    • Target information above from: UniProt accession Q99626 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 618679 Cow
      • Entrez Gene: 1045 Human
      • Omim: 600297 Human
      • SwissProt: Q99626 Human
      • Unigene: 174249 Human
      • Alternative names

        • Caudal type homeo box 2 antibody
        • Caudal type homeo box transcription factor 2 antibody
        • Caudal type homeobox 2 antibody
        • Caudal type homeobox protein 2 antibody
        • Caudal type homeobox transcription factor 2 antibody
        • Caudal-type homeobox protein 2 antibody
        • CDX 2 antibody
        • CDX 3 antibody
        • CDX-3 antibody
        • Cdx2 antibody
        • CDX2/AS antibody
        • CDX2_HUMAN antibody
        • CDX3 antibody
        • Homeobox protein CDX 2 antibody
        • Homeobox protein CDX-2 antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CDX2 antibody (ab70458)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CDX2 antibody (ab70458)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human ovarian carcinoma tissue labelling CDX2 with ab70458 at 1/1000 (1µg/ml). Detection: DAB.

      Protocols

      • Immunohistochemistry protocols

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
      • SDS
    • References (1)

      Publishing research using ab70458? Please let us know so that we can cite the reference in this datasheet.

      ab70458 has been referenced in 1 publication.

      • Chu X  et al. Establishment and characterization of a novel cell line (cc-006cpm8) of moderately/poorly differentiated colorectal adenocarcinoma derived from a primary tumor of a patient. Int J Oncol 55:243-256 (2019). PubMed: 31115570

      Customer reviews and Q&As

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