Key features and details
- Mouse monoclonal [C66/261] to CEACAM1 + CEACAM5
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
Product nameAnti-CEACAM1 + CEACAM5 antibody [C66/261]
See all CEACAM1 + CEACAM5 primary antibodies
DescriptionMouse monoclonal [C66/261] to CEACAM1 + CEACAM5
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Tissue, cells or virus corresponding to Human CEACAM1 + CEACAM5. Human colon carcinoma extract
Database link: P06731
- IHC-P: Human colon carcinoma tissue
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.05% Sodium azide
Constituents: 0.05% BSA, 99% PBS
Concentration information loading...
PurityProtein G purified
Light chain typekappa
Our Abpromise guarantee covers the use of ab190718 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 0.25 - 0.5 µg/ml. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.|
RelevanceCEACAM1 and CEACAM5 belong to the carcinoembryonic antigen (CEA) gene family. It is expressed on cells of epithelial and myeloid origin. CEACAM1 expression is downregulated in many tumors indicating a tumor - suppressive function. The antitumor effect may be due to inhibition of tumor angiogenesis, possibly by increased secretion of antiangiogenic molecules from the cells. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by two immunoglobulin constant-like A (A1, A2) and one B domain. While the N, A1 and B domains can also be found in other CEA-family members, the A2 domain of CEACAM1 differs from those found in other CEACAM. CEACAM5 is a cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. CEACAM5 is a homodimer. It is a receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
Cellular localizationIsoforms A, B, C: Cell membrane; Single-pass type I membrane protein. Isoforms G, H, I: Secreted.
- Antigen CD66e antibody
- ATP dependent taurocolate carrier protein antibody
- BGP 1 antibody
ab190718 has not yet been referenced specifically in any publications.