Overview

  • Product name

  • Description

    Rabbit polyclonal to CEACAM3
  • Host species

    Rabbit
  • Specificity

    ab196606 detects endogenous level of total CEACAM3 protein
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment within Human CEACAM3 (N terminal). The exact sequence is proprietary.
    Database link: P40198

  • Positive control

    • A549 whole cell lysate (ab7910) can be used as a positive control in WB. Paraffin-embedded human epididymis, Human lung and Human testis tissue. A459, HT29, Mous eliver, Mouse lung and Mouse testis lysates.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.4
    Preservative: 0.02% Sodium azide
    Constituents: 50% Glycerol, 0.87% Sodium chloride, 49% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab196606 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200.
WB 1/500 - 1/2000. Predicted molecular weight: 27 kDa.

Target

  • Function

    Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.
  • Tissue specificity

    CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney.
  • Sequence similarities

    Belongs to the immunoglobulin superfamily. CEA family.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Domain

    The cytosolic domain is involved in S100A9 interaction.
  • Post-translational
    modifications

    Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • carcinoembryonic antibody
    • Carcinoembryonic antigen CGM1 antibody
    • Carcinoembryonic antigen gene family member 1 antibody
    • carcinoembryonic antigen related cell adhesion molecule 3 antibody
    • Carcinoembryonic antigen-related cell adhesion molecule 3 antibody
    • cd66 d antibody
    • CD66d antibody
    • CD66d antigen antibody
    • CEA antibody
    • CEACAM 3 antibody
    • CEACAM-3 antibody
    • Ceacam3 antibody
    • CEAM 3 antibody
    • CEAM-3 antibody
    • CEAM3 antibody
    • CEAM3_HUMAN antibody
    • CGM1 antibody
    • Nonspecific cross reacting antigen antibody
    • W264 antibody
    • W282 antibody
    see all

Images

  • All lanes : Anti-CEACAM3 antibody (ab196606) at 1/500 dilution

    Lane 1 : A549 cell lysate
    Lane 2 : HT29 cell lysate
    Lane 3 : Mouse liver lysate
    Lane 4 : Mouse lung lysate
    Lane 5 : Mouse testis lysate

    Predicted band size: 27 kDa

  • Immunohistochemical analysis of paraffin-embedded human epididymis labeling CEACAM3 using ab196606 at 1/100 dilution 

  • Immunohistochemical analysis of paraffin-embedded human lung labeling CEACAM3 using ab196606 at 1/100 dilution.

  • Immunohistochemical analysis of paraffin-embedded human testis labeling CEACAM3 using ab196606 at 1/100 dilution.

References

ab196606 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab196606.
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