Overview

  • Product name

    Ceefourin™ 2, MRP4 inhibitor inhibitor
  • Description

    Highly selective multidrug resistance protein 4 (MRP4) inhibitor
  • Biological description

    Highly selective multidrug resistance protein 4 (MRP4) inhibitor (IC50 = 7 µM). Blocked transport of MRP4 substrates, including 6-Mercaptopurine, SN 38, D-Luciferin and E217βG. No detectable effect on MRP4 homologs MRP1, 2, 3 or 5, and related transporters P-gp and ABCG2 in vitro. Low cellular toxicity, and high microsomal and acid stability. Chemically distinctive to Ceefourin™ 1 (ab145144).
  • Purity

    > 98%
  • General notes

    Sold under exclusive licence from Children's Cancer Institute. Ceefourin™ is a trademark of Children's Cancer Institute.
  • CAS Number

    348148-51-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-Chloro-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid
  • Molecular weight

    355.70
  • Molecular formula

    C15H9ClF3N3O2
  • PubChem identifier

    1366977
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    FC(F)(F)c1cc(nc2c(Cl)c(nn12)C(=O)O)c3ccc(C)cc3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Cheung L  et al. High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4). Biochem Pharmacol 91:97-108 (2014). Read more (PubMed: 24973542) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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