Overview

  • Product name

    Cefotaxime sodium, cephalosporin antibiotic
  • Description

    Third-generation cephalosporin antibiotic
  • Biological description

    Third-generation cephalosporin antibiotic. Binds to the penicillin-binding proteins (PBPs) therefore inhibiting the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. Active in vitro and in vivo.
  • Purity

    > 96%
  • CAS Number

    64485-93-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Sodium (6R,7R)-3-(Acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • Molecular weight

    477.45
  • Molecular formula

    C16H16N5NaO7S
  • PubChem identifier

    10695961
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=O)OCC1=C(N2C(C(C2=O)NC(=O)C(=NOC)C3=CSC(=N3)N)SC1)C(=O)[O-].[Na+]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Sharma R  et al. Insights into the binding of the drugs diclofenac sodium and cefotaxime sodium to serum albumin: calorimetry and spectroscopy. Eur J Pharm Sci 46:435-45 (2012). Read more (PubMed: 22483968) »
  • Chen D  et al. Chemiluminescence determination of cefotaxime sodium with flow-injection analysis of cerium (IV)-rhodamine 6G system and its application to the binding study of cefotaxime sodium to protein with on-line microdialysis sampling. Spectrochim Acta A Mol Biomol Spectrosc 78:553-7 (2011). Read more (PubMed: 21050805) »
  • Morelli B Derivative spectrophotometry in the analysis of mixtures of cefotaxime sodium and cefadroxil monohydrate. J Pharm Biomed Anal 32:257-67 (2003). Read more (PubMed: 12763535) »

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