Celecoxib (Celebrex), cyclooxygenase-2 (COX-2) inhibitor (ab141988)
Key features and details
- Selective cyclooxygenase-2 (COX-2) inhibitor. Non-steroidal anti-inflammatory drug.
- CAS Number: 169590-42-5
- Soluble in DMSO to 25 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Celecoxib (Celebrex), cyclooxygenase-2 (COX-2) inhibitor -
Description
Selective cyclooxygenase-2 (COX-2) inhibitor. Non-steroidal anti-inflammatory drug. -
Biological description
Selective COX-2 inhibitor (IC50 values are 15 and 0.04 μM for COX-1 and COX-2 respectively). Non-steroidal anti-inflammatory drug. Enhances tumor cell apoptosis in vivo. Orally active.
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CAS Number
169590-42-5 -
Chemical structure
Properties
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Chemical name
4-[5-(4-Methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide -
Molecular weight
381.37 -
Molecular formula
C17H14F3N3O2S -
PubChem identifier
2662 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM and in ethanol to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F -
Source
Synthetic
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Research areas
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (4)
ab141988 has been referenced in 4 publications.
- Dey R & Bishayi B TLR-2 neutralization potentiates microglial M1 to M2 switching by the combinatorial treatment of ciprofloxacin and dexamethasone during S. aureus infection. J Neuroimmunol 344:577262 (2020). PubMed: 32450430
- Harati R et al. Loss of miR-101-3p Promotes Transmigration of Metastatic Breast Cancer Cells through the Brain Endothelium by Inducing COX-2/MMP1 Signaling. Pharmaceuticals (Basel) 13:N/A (2020). PubMed: 32645833
- Naji S et al. Cadmium Induces Migration of Colon Cancer Cells: Roles of Reactive Oxygen Species, P38 and Cyclooxygenase-2. Cell Physiol Biochem 52:1517-1534 (2019). PubMed: 31120230
- Chen L et al. L161982 alleviates collagen-induced arthritis in mice by increasing Treg cells and down-regulating Interleukin-17 and monocyte-chemoattractant protein-1 levels. BMC Musculoskelet Disord 18:462 (2017). PubMed: 29145862