Recombinant
RabMAb

Recombinant Anti-Cellular Apoptosis Susceptibility/CSE1L antibody [EPR10326(B)] (ab150432)

Overview

  • Product name

    Anti-Cellular Apoptosis Susceptibility/CSE1L antibody [EPR10326(B)]
    See all Cellular Apoptosis Susceptibility/CSE1L primary antibodies
  • Description

    Rabbit monoclonal [EPR10326(B)] to Cellular Apoptosis Susceptibility/CSE1L
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human Cellular Apoptosis Susceptibility/CSE1L aa 1-100 (N terminal). The exact sequence is proprietary.
    Database link: P55060

  • Positive control

    • HeLa, MOLT4, MCF7 and Ramos cell lysates.
  • General notes

     

     

     This product was previously labelled as Cellular Apoptosis Susceptibility

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab150432 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 110 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • Function

      Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
    • Tissue specificity

      Highly expressed in proliferating cells.
    • Sequence similarities

      Belongs to the XPO2/CSE1 family.
      Contains 1 importin N-terminal domain.
    • Cellular localization

      Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm.
    • Information by UniProt
    • Database links

    • Alternative names

      • CAS antibody
      • Cellular apoptosis susceptibility protein antibody
      • Chromosome segregation 1 (yeast homolog) like antibody
      • Chromosome segregation 1 Like antibody
      • Chromosome segregation 1 like protein antibody
      • Chromosome segregation 1-like protein antibody
      • Chromosome segregation gene CSE1 antibody
      • CSE 1 antibody
      • CSE 1 chromosome segregation 1 like antibody
      • CSE 1 chromosome segregation 1 like protein antibody
      • CSE 1L antibody
      • CSE1 antibody
      • CSE1 chromosome segregation 1 like (yeast) antibody
      • CSE1 chromosome segregation 1 like antibody
      • CSE1 chromosome segregation 1 like protein antibody
      • CSE1L antibody
      • Exp 2 antibody
      • Exp2 antibody
      • Exportin 2 antibody
      • Exportin-2 antibody
      • Exportin2 antibody
      • Importin alpha re exporter antibody
      • Importin-alpha re-exporter antibody
      • MGC117283 antibody
      • MGC130036 antibody
      • MGC130037 antibody
      • XPO 2 antibody
      • XPO2 antibody
      • XPO2_HUMAN antibody
      see all

    Images

    • All lanes : Anti-Cellular Apoptosis Susceptibility/CSE1L antibody [EPR10326(B)] (ab150432) at 1/1000 dilution

      Lane 1 : HeLa cell lysate
      Lane 2 : MOLT4 cell lysate
      Lane 3 : MCF7 cell lysate
      Lane 4 : Ramos cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat anti-rabbit HRP at 1/2000 dilution

      Predicted band size: 110 kDa

    References

    ab150432 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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