Product nameAnti-Cellular Apoptosis Susceptibility/CSE1L antibody [EPR10326(B)]
See all Cellular Apoptosis Susceptibility/CSE1L primary antibodies
DescriptionRabbit monoclonal [EPR10326(B)] to Cellular Apoptosis Susceptibility/CSE1L
Tested applicationsSuitable for: WBmore details
Unsuitable for: Flow Cyt,ICC,IHC-P or IP
Species reactivityReacts with: Mouse, Rat, Human
Synthetic peptide within Human Cellular Apoptosis Susceptibility/CSE1L aa 1-100 (N terminal). The exact sequence is proprietary.
Database link: P55060
- HeLa, MOLT4, MCF7 and Ramos cell lysates.
Storage instructionsShipped at 4°C. Store at -20ºC.
Storage bufferPreservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue culture supernatant
PurityTissue culture supernatant
Our Abpromise guarantee covers the use of ab150432 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000 - 1/10000. Predicted molecular weight: 110 kDa.|
FunctionExport receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Tissue specificityHighly expressed in proliferating cells.
Sequence similaritiesBelongs to the XPO2/CSE1 family.
Contains 1 importin N-terminal domain.
Cellular localizationCytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm.
- Information by UniProt
- CAS antibody
- Cellular apoptosis susceptibility protein antibody
- Chromosome segregation 1 (yeast homolog) like antibody
All lanes : Anti-Cellular Apoptosis Susceptibility/CSE1L antibody [EPR10326(B)] (ab150432) at 1/1000 dilution
Lane 1 : HeLa cell lysate
Lane 2 : MOLT4 cell lysate
Lane 3 : MCF7 cell lysate
Lane 4 : Ramos cell lysate
Lysates/proteins at 10 µg per lane.
All lanes : Goat anti-rabbit HRP at 1/2000 dilution
Predicted band size: 110 kDa
ab150432 has not yet been referenced specifically in any publications.