Overview

  • Product name

    Anti-Centaurin alpha 1 antibody - N-terminal
    See all Centaurin alpha 1 primary antibodies
  • Description

    Rabbit polyclonal to Centaurin alpha 1 - N-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Recombinant fragment corresponding to Human Centaurin alpha 1 (N terminal).
    Database link: O75689

  • Positive control

    • Mouse brain lysate; Human colon cancer tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab197380 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/200.
WB 1/200 - 1/1000. Predicted molecular weight: 43 kDa.

Target

  • Relevance

    The centaurin alpha 1 protein is a high affinity PtdIns(3,4,5)P3 binding protein enriched in brain. By acting as a GTPase activating protein for ADP ribosylation factor 6 (ARF6), centaurin alpha 1 is able to switch off ARF6 and inhibit its ability to mediate beta 2 adrenoceptor internalization and negatively regulates ARF6 activity by functioning as an in vivo PIP3 dependent ARF6 GAP.
  • Cellular localization

    Cytoplasmic, Nuclear and Plasma membrane
  • Database links

  • Alternative names

    • ArfGAP with dual PH domains 1 antibody
    • CENTA 1 antibody
    • CENTA1 antibody
    • Centaurin alpha antibody
    • GCS1L antibody
    • p42IP4 antibody
    • Putative MAPK activating protein PM25 antibody
    see all

Images

  • Anti-Centaurin alpha 1 antibody - N-terminal (ab197380) at 1/500 dilution + mouse brain lysate at 40 µg

    Secondary
    Anti-rabbit IgG at 1/8000 dilution

    Predicted band size: 43 kDa


    Exposure time: 15 seconds
  • Immunohistochemical analysis of paraffin-embedded human colon cancer tissue, labeling Centaurin alpha 1 with ab197380 at a 1/100 dilution.

References

ab197380 has not yet been referenced specifically in any publications.

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