Overview

  • Product name

  • Description

    Rabbit polyclonal to Centrobin
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse
    Predicted to work with: Human, Rhesus monkey
  • Immunogen

    Recombinant fragment within Human Centrobin (internal sequence). The exact sequence is proprietary.
    Database link: Q8N137

  • Positive control

    • WB: Mouse intestine and testis tissues.
  • General notes

    Protein previously labeled as CNTROB.

Properties

Applications

Our Abpromise guarantee covers the use of ab227913 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000.

Target

  • Function

    Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.
  • Tissue specificity

    Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.
  • Developmental stage

    Preferentially incorporated into the newly assembled daughter centriole during centriole assembly at the late G1 or early S phase. Remains in the daughter centrioles throughout the cell cycle. At the next cycle of centriole duplication, its amount on the original daughter centriole eventually decreases.
  • Post-translational
    modifications

    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization

    Cytoplasm > cytoskeleton > centrosome > centriole. Centriole-associated, asymmetrically localizes to the daughter centriole.
  • Information by UniProt
  • Database links

  • Alternative names

    • 9830165K03Rik antibody
    • Centrobin antibody
    • centrobin, centrosomal BRCA2 interacting protein antibody
    • Centrosomal BRCA2 interacting protein antibody
    • Centrosomal BRCA2-interacting protein antibody
    • CNTRB_HUMAN antibody
    • Cntrob antibody
    • LIP8 antibody
    • LYST interacting protein 8 antibody
    • LYST-interacting protein 8 antibody
    • LYST-interacting protein LIP8 antibody
    • PP1221 antibody
    • RGD1307488 antibody
    • RP23 26L6.9 antibody
    see all

Images

  • Paraffin-embedded mouse intestine tissue stained for Centrobin using ab227913 at 1/500 dilution in immunohistochemical analysis.

  • Paraffin-embedded mouse testis tissue stained for Centrobin using ab227913 at 1/500 dilution in immunohistochemical analysis.

References

ab227913 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab227913.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up