Overview

  • Product name

  • Description

    Rabbit polyclonal to CEP152
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human CEP152 aa 58-264. The exact sequence is proprietary.
    Database link: O94986

  • Positive control

    • WB: HEK-293T and HeLa whole cell lysate (ab150035). ICC/IF: HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab183911 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 189 kDa.
ICC/IF 1/100 - 1/1000.

Target

  • Involvement in disease

    Defects in CEP152 are the cause of microcephaly primary type 4 (MCPH4) [MIM:604321]. A disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder.
  • Cellular localization

    Cytoplasm > cytoskeleton > centrosome.
  • Information by UniProt
  • Database links

  • Alternative names

    • Asterless antibody
    • CE152_HUMAN antibody
    • Centrosomal protein 152kDa antibody
    • Centrosomal protein of 152 kDa antibody
    • Cep152 antibody
    • FLJ21594 antibody
    • KIAA0912 antibody
    • MCPH4 antibody
    • MCPH9 antibody
    • Microcephaly primary autosomal recessive 4 antibody
    • SCKL5 antibody
    see all

Images

  • Immunofluorescent analysis of  HeLa cells (fixed in 2% paraformaldehyde/culture medium at 37℃ for 30 min) labeling CEP152 with ab183911 at 1/2000 dilution. Right panel costained with Hoechst 33342 (blue) and alpha 1b tubulin antibody at 1/5000 dilution (red).



     

  • All lanes : Anti-CEP152 antibody (ab183911) at 1/1000 dilution

    Lane 1 : HEK-293T whole cell lysate
    Lane 2 : HeLa whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 189 kDa



    5% SDS-PAGE

References

This product has been referenced in:

  • Kim J  et al. PCNT is critical for the association and conversion of centrioles to centrosomes during mitosis. J Cell Sci 132:N/A (2019). Read more (PubMed: 30814333) »
  • Yaguchi K  et al. Uncoordinated centrosome cycle underlies the instability of non-diploid somatic cells in mammals. J Cell Biol 217:2463-2483 (2018). Read more (PubMed: 29712735) »
See all 4 Publications for this product

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