Overview

  • Product name

    Anti-Ceramide glucosyltransferase antibody
    See all Ceramide glucosyltransferase primary antibodies
  • Description

    Rabbit polyclonal to Ceramide glucosyltransferase
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Drosophila melanogaster, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 35-84 of Human Ceramide glucosyltransferase (NP_003349).

  • Positive control

    • Fetal spleen lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab98030 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 45 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function

    Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase".
  • Tissue specificity

    Found in all tissues examined.
  • Pathway

    Lipid metabolism; sphingolipid metabolism.
  • Sequence similarities

    Belongs to the glycosyltransferase 2 family.
  • Cellular localization

    Golgi apparatus membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CEGT_HUMAN antibody
    • Ceramide glucosyltransferase antibody
    • GCS antibody
    • GLCT 1 antibody
    • GLCT-1 antibody
    • GLCT1 antibody
    • Glucosylceramide synthase antibody
    • UDP glucose ceramide glucosyltransferase antibody
    • UDP glucose N acylsphingosine D glucosyltransferase antibody
    • UDP-glucose ceramide glucosyltransferase antibody
    • UDP-glucose:N-acylsphingosine D-glucosyltransferase antibody
    • Ugcg antibody
    see all

Images

  • Anti-Ceramide glucosyltransferase antibody (ab98030) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal spleen lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size: 45 kDa



    Gel concentration: 12%

References

This product has been referenced in:

  • Grimm MO  et al. PS dependent APP cleavage regulates glucosylceramide synthase and is affected in Alzheimer's disease. Cell Physiol Biochem 34:92-110 (2014). Read more (PubMed: 24977484) »
  • Gramatzki D  et al. Glioma cell death induced by irradiation or alkylating agent chemotherapy is independent of the intrinsic ceramide pathway. PLoS One 8:e63527 (2013). WB ; Human . Read more (PubMed: 23667632) »
See all 2 Publications for this product

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