Overview

  • Product name

    Cercosporin, PKC inhibitor
  • Description

    Light-induced phytotoxin. Potent, selective competitive PKC inhibitor.
  • Biological description

    Light-induced phytotoxin. Potent, selective competitive PKC inhibitor. Shows antiproliferative effects (IC50 = 4.68 μM, MCF7 cancer cell lines). Shows antimicrobial and antiparasitic effects in vivo.
  • Purity

    > 95%
  • CAS Number

    35082-49-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6,11-Dihydroxy-8,9-bis(2-hydroxypropyl)-7,10-dimethoxyperylo[1,12-def][1,3]dioxepine-5,12-dione
  • Molecular weight

    534.51
  • Molecular formula

    C29H26O10
  • PubChem identifier

    2674
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol and in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(CC1=C(C(=C2C(=O)C=C3C4=C5C(=CC(=O)C6=C(C(=C(C(=C56)C1=C42)CC(C)O)OC)O)OCO3)O)OC)O
  • Source

    Cercospora sp.

  • Research areas

References

This product has been referenced in:

  • Morgan BJ  et al. Design, synthesis, and investigation of protein kinase C inhibitors: total syntheses of (+)-calphostin D, (+)-phleichrome, cercosporin, and new photoactive perylenequinones. J Am Chem Soc 131:9413-25 (2009). Read more (PubMed: 19489582) »
  • Vandenbogaerde AL  et al. Cytotoxicity and antiproliferative effect of hypericin and derivatives after photosensitization. Photochem Photobiol 67:119-25 (1998). Read more (PubMed: 9477769) »
  • Barak D  et al. Structural investigation of protein kinase C inhibitors. J Mol Struct 230:419-29 (1991). Read more (PubMed: 11538178) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab144218.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up