Cerivastatin sodium, HMG-CoA reductase inhibitor (ab142853)

Overview

  • Product name

    Cerivastatin sodium, HMG-CoA reductase inhibitor
  • Description

    Potent HMG-CoA reductase inhibitor
  • Biological description

    Potent HMG-CoA reductase inhibitor (Ki = 13 nM). Shows higher potency than Lovastatin (ab120614). Enantiomerically pure pyridine derivative. Reduces plasma cholesterol levels in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    143201-11-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (E,3R,5S)-7-[4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-di(propan-2-yl)pyridin-3-yl]-3,5-dihydroxyhept-6-enoate sodium
  • Molecular weight

    481.53
  • Molecular formula

    C26H33FNNaO5
  • PubChem identifier

    23663992
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)C1=C(C(=C(C(=N1)C(C)C)C=CC(CC(CC(=O)[O-])O)O)C2=CC=C(C=C2)F)COC.[Na+]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Shiomi M & Ito T Effect of cerivastatin sodium, a new inhibitor of HMG-CoA reductase, on plasma lipid levels, progression of atherosclerosis, and the lesional composition in the plaques of WHHL rabbits. Br J Pharmacol 126:961-8 (1999). Read more (PubMed: 10193776) »
  • Bischoff H  et al. Preclinical review of cerivastatin sodium--a step forward in HMG-CoA reductase inhibition. Atherosclerosis 139 Suppl 1:S7-13 (1998). Read more (PubMed: 9811153) »
  • Yasunobu Y  et al. Reduction of plasma cholesterol levels and induction of hepatic LDL receptor by cerivastatin sodium (CAS 143201-11-0, BAY w 6228), a new inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, in dogs. Cardiovasc Drugs Ther 11:567-74 (1997). Read more (PubMed: 9358961) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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