Overview

  • Product name

  • Description

    Rabbit polyclonal to CERKL
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human CERKL (internal sequence). NP_001025482
    Database link: Q49MI3

  • Positive control

    • HeLa cell lysate

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.3
    Preservative: 0.05% Sodium azide
    Constituents: 49% PBS, 50% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab198918 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 63 kDa.

Target

  • Function

    Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions.
  • Tissue specificity

    Isoform 1 and isoform 2 are expressed in adult retina, liver and pancreas as well as in fetal brain, lung and kidney. Isoform 3 is expressed in adult retina as well as in fetal lung and liver. Isoform 4 is expressed in adult retina, lung and kidney as well as in fetal lung and liver. Moderately expressed in retina, kidney, lung, testis, trachea, and pancreas. Weakly expressed in brain, placenta and liver.
  • Involvement in disease

    Defects in CERKL are the cause of retinitis pigmentosa type 26 (RP26) [MIM:608380]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP26 inheritance is autosomal recessive.
  • Sequence similarities

    Contains 1 DAGKc domain.
  • Developmental stage

    Expressed in fetal lung, kidney and brain.
  • Post-translational
    modifications

    Phosphorylated on serine residues.
  • Cellular localization

    Cytoplasm. Nucleus > nucleolus. Enriched in nucleoli. May shuttle between nucleus and cytoplasm. Isoform 5 is not enriched in the nucleoli and Cytoplasm. Nucleus > nucleolus. Golgi apparatus > trans-Golgi network. Endoplasmic reticulum.
  • Information by UniProt
  • Database links

  • Alternative names

    • Ceramide kinase like protein antibody
    • Ceramide kinase-like protein antibody
    • CERKL antibody
    • CERKL_HUMAN antibody
    • Retinitis pigmentosa 26 (autosomal recessive) antibody
    • RP26 antibody
    see all

Images

  • Anti-CERKL antibody (ab198918) at 1/1100 dilution + HeLa cell lysate at 40 µg

    Predicted band size: 63 kDa


    Exposure time: 1 minute


    Gel: 6% SDS-PAGE.

References

ab198918 has not yet been referenced specifically in any publications.

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