Overview

  • Product name

    Anti-Ceruloplasmin antibody (Biotin)
    See all Ceruloplasmin primary antibodies
  • Description

    Rabbit polyclonal to Ceruloplasmin (Biotin)
  • Host species

    Rabbit
  • Conjugation

    Biotin
  • Tested applications

    Suitable for: RIA, IP, WB, ELISAmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Human Ceruloplasmin purified from human plasma

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 50% Glycerol, PBS, pH 7.5
  • Concentration information loading...
  • Purity

    Protein G purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab48650 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
RIA Use at an assay dependent concentration.
IP Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Predicted molecular weight: 122 kDa.
ELISA Use at an assay dependent concentration.

Target

  • Function

    Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane.
  • Tissue specificity

    Expressed by the liver and secreted in plasma.
  • Involvement in disease

    Defects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.
    Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2.
  • Sequence similarities

    Belongs to the multicopper oxidase family.
    Contains 3 F5/8 type A domains.
    Contains 6 plastocyanin-like domains.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • CERU_HUMAN antibody
    • Ceruloplasmin antibody
    • CP 2 antibody
    • CP antibody
    • CP2 antibody
    • Ferroxidase antibody
    see all

References

ab48650 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Answer

Gracias por contactarnos.
Este anticuerpo nos lo proporciona un colaborador externo, que lamentablemente no comparte los detalles acerca de la conjugación del anticuerpo. Lo único que nos ha confirmado es que la biotinilación del anticuerpo se ha hecho de forma totalmente aleatoria, no dirigida.
En cualquier caso, por si os sirviera de referencia te mando el enlace a nuestra página acerca de los kits de conjugación, que quizás os sea útil para entender mejor el proceso de conjugación con biotina. Otro link interesante acerca de la conjugación con biotina puede accederse desde aquí.
Siento no tener más información disponible. En cualquier caso, si necesitáis más información no dudéis en contactarnos de nuevo.

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