Key features and details
- Rabbit polyclonal to Ceruloplasmin (Biotin)
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG
Product nameAnti-Ceruloplasmin antibody (Biotin)
See all Ceruloplasmin primary antibodies
DescriptionRabbit polyclonal to Ceruloplasmin (Biotin)
Species reactivityReacts with: Human
Human Ceruloplasmin purified from human plasma
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.50
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: PBS, 50% Glycerol
Concentration information loading...
PurityProtein G purified
FunctionCeruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane.
Tissue specificityExpressed by the liver and secreted in plasma.
Involvement in diseaseDefects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.
Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2.
Sequence similaritiesBelongs to the multicopper oxidase family.
Contains 3 F5/8 type A domains.
Contains 6 plastocyanin-like domains.
- Information by UniProt
- CERU_HUMAN antibody
- Ceruloplasmin antibody
- CP 2 antibody
ab48650 has not yet been referenced specifically in any publications.