Product nameAnti-Ceruloplasmin antibody [EPSISR6-42]
See all Ceruloplasmin primary antibodies
DescriptionRabbit monoclonal [EPSISR6-42] to Ceruloplasmin
Tested applicationsSuitable for: ICC/IF, WBmore details
Unsuitable for: IHC-P or IP
Species reactivityReacts with: Human
Synthetic peptide, corresponding to residues in Human Ceruloplasmin (Uniprot: P00450).
- Human plasma and serum; HepG2 cells.
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Storage instructionsShipped at 4°C. Store at -20ºC.
Storage bufferPreservative: 0.01% Sodium azide
Constituents: 40% Glycerol, 0.05% BSA, 9% PBS
Concentration information loading...
PurityTissue culture supernatant
Our Abpromise guarantee covers the use of ab157452 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||1/100 - 1/250.|
|WB||1/1000 - 1/5000. Predicted molecular weight: 122 kDa.|
FunctionCeruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane.
Tissue specificityExpressed by the liver and secreted in plasma.
Involvement in diseaseDefects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.
Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2.
Sequence similaritiesBelongs to the multicopper oxidase family.
Contains 3 F5/8 type A domains.
Contains 6 plastocyanin-like domains.
- Information by UniProt
- CERU_HUMAN antibody
- Ceruloplasmin antibody
- CP 2 antibody
All lanes : Anti-Ceruloplasmin antibody [EPSISR6-42] (ab157452) at 1/1000 dilution
Lane 1 : Human plasma cell lysate
Lane 2 : Human serum cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size: 122 kDa
Immunofluorescent analysis of HepG2 cells labeling Ceruloplasmin with ab157452 at 1/100 dilution.