Recombinant
RabMAb

Recombinant Anti-Ceruloplasmin antibody [EPSISR6-42] (ab157452)

Overview

  • Product name

    Anti-Ceruloplasmin antibody [EPSISR6-42]
    See all Ceruloplasmin primary antibodies
  • Description

    Rabbit monoclonal [EPSISR6-42] to Ceruloplasmin
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IF, WBmore details
    Unsuitable for: IHC-P or IP
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide, corresponding to residues in Human Ceruloplasmin (Uniprot: P00450).

  • Positive control

    • Human plasma and serum; HepG2 cells.
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab157452 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/100 - 1/250.
WB 1/1000 - 1/5000. Predicted molecular weight: 122 kDa.
  • Application notes
    Is unsuitable for IHC-P or IP.
  • Target

    • Function

      Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane.
    • Tissue specificity

      Expressed by the liver and secreted in plasma.
    • Involvement in disease

      Defects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.
      Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2.
    • Sequence similarities

      Belongs to the multicopper oxidase family.
      Contains 3 F5/8 type A domains.
      Contains 6 plastocyanin-like domains.
    • Cellular localization

      Secreted.
    • Information by UniProt
    • Database links

    • Alternative names

      • CERU_HUMAN antibody
      • Ceruloplasmin antibody
      • CP 2 antibody
      • CP antibody
      • CP2 antibody
      • Ferroxidase antibody
      see all

    Images

    • All lanes : Anti-Ceruloplasmin antibody [EPSISR6-42] (ab157452) at 1/1000 dilution

      Lane 1 : Human plasma cell lysate
      Lane 2 : Human serum cell lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 122 kDa

    • Immunofluorescent analysis of HepG2 cells labeling Ceruloplasmin with ab157452 at 1/100 dilution.

    References

    This product has been referenced in:

    • Xiao Q  et al. LRIG2 promotes the proliferation and cell cycle progression of glioblastoma cells in vitro and in vivo through enhancing PDGFRß signaling. Int J Oncol 53:1069-1082 (2018). Read more (PubMed: 30015847) »
    See 1 Publication for this product

    Customer reviews and Q&As

    Answer

    I can confirm that ab157452 and ab131220 were produced from same monoclonal antibody production project [EPSISR6] using the same immunogen. However, they are different clones that were produced from this project.

    They are tested and covered by the guarantee for different applications.

    ab157452 clone SISR6-42
    Suitable for :ICC, WB
    Reacts with: human

    ab131220 SISR6-12
    Suitable for WB
    Reacts with: rat, human

    Our datasheet team currently adding more detailed clone number information to the datasheets.

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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